Thirty three patients with stable effort-associated angina (Functional Class II) were examined. Enhanced lipid hydroperoxide levels in plasma lipids from the patients were found to play a pathogenetic role in the disturbance of platelet microcirculatory homeostasis. The calcium antagonist finoptin used in combination with alpha-tocopherol made it possible to decrease lipid hydroperoxide levels in low density lipoproteins and malondialdehyde concentrations in platelets, to prevent abnormal cyclic nucleotide metabolism in them and to increase tolerance to physical exercise.
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