Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Microbes Infect

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

Published: March 2017

Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.

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Source
http://dx.doi.org/10.1016/j.micinf.2016.10.005DOI Listing

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