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The 'Oma's of the Gammas-Cancerogenesis by γ-Herpesviruses.
Viruses
December 2024
Division of Virology, ICMR-National Institute of Translational Virology and AIDS Research, Pune 411026, MH, India.
Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), which are the only members of the gamma(γ) herpesviruses, are oncogenic viruses that significantly contribute to the development of various human cancers, such as Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphoma, Kaposi's sarcoma, and primary effusion lymphoma. Oncogenesis triggered by γ-herpesviruses involves complex interactions between viral genetics, host cellular mechanisms, and immune evasion strategies. At the genetic level, crucial viral oncogenes participate in the disruption of cell signaling, leading to uncontrolled proliferation and inhibition of apoptosis.
View Article and Find Full Text PDFMechanism and Kinetics of HIV-1 Protease Activation.
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November 2024
Center for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
The HIV-1 protease is a critical enzyme for viral replication. Because protease activity is necessary to generate mature infectious virions, it is a primary target of antiretroviral treatment. Here, we provide an overview of the mechanisms regulating protease activation and the methods available to assess protease activity.
View Article and Find Full Text PDFUnderstanding the Epidemiology of Monkeypox Virus to Prevent Future Outbreaks.
Microorganisms
December 2024
Fundación Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain.
Monkeypox (Mpox) is an infectious disease caused by the Mpox virus belonging to the Orthopoxvirus genus in the Poxviridae family and has been declared by the WHO as a global health emergency owing to its rapid spread during 2022 and 2023. All patients diagnosed with Mpox who were confirmed by PCR between July 2022 and April 2023 were included in this study. In total, 405 patients in whom clade 2 was identified were included.
View Article and Find Full Text PDFComparison of Standard and Point-of-Care CD4+ T Lymphocyte Measurement Methods in HIV-1 Infected Turkish Patients.
Medicina (Kaunas)
December 2024
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kocaeli University, Kocaeli 41001, Turkey.
: CD4+ T lymphocytes are the primary targets of HIV infection. CD4+ T lymphocyte count is an indicator of immune competence. In this study, we aimed to compare standard flow cytometry and point-of-care (POC) CD4+ T lymphocyte in terms of cost, effectiveness, reliability, time, and the use of this method for disease.
View Article and Find Full Text PDFEvaluating the Implementation of Adolescent- and Youth-Friendly Services in the Selected Primary Healthcare Facilities in Vhembe District, Limpopo Province.
Int J Environ Res Public Health
November 2024
Department of Public Health, Faculty of Health Sciences, University of Venda, Thohoyandou 0950, Limpopo, South Africa.
Background: The adolescent- and youth-friendly services (AYFS) programme has the potential to address several diverse problems within adolescents' healthcare systems by improving the quality, accessibility, efficiency, and effectiveness of healthcare services. The country continues to suffer from structural and systemic factors that hinder the effective provision and implementation of AYFS despite its comprehensive legal and policy framework and commitment to enhancing young people's health. Vhembe District has not been evaluated regarding the implementation of AYFS based on WHO global standards.
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