Background: Preoperative nutritional deficiency (ND) has been shown to be a valuable prognostic factor in urologic malignancies. We aimed to investigate the prognostic value of ND in patients with gastric cancer (GC).
Methods: A single-center cohort of 1026 GC patients undergoing curative resection between 2003 and 2012 was categorized to ND and nutritionally replete (NR) groups. Patients with body mass index <18.5 kg/m, preoperative albumin <35 g/l, or preoperative weight loss ≥5% of body weight were defined as ND.
Results: Of the 1026 patients included in the study, 585 (57.0%) were categorized as ND. Overall survival (OS) at 5 years was 68.5% for ND patients and 44.0% for NR patients (P<.001). Multivariate analysis revealed that ND was a significant predictor of OS (hazard ratio: 1.954; 95% confidence interval: 1.552-2.460; P<.001). In stage-stratified analysis, it was still independently associated with OS in tumor-nodes-metastasis stage II and III (P=.004 and P<.001, respectively). Of note, the prognostic significance of ND was still maintained when stratified by age, sex, anemia, and adjuvant chemotherapy (all Ps<.05).
Conclusion: Preoperative ND is a novel predictor of outcome in GC, especially in stage II to III GC, and may help clinicians identify high-risk patients for proactive nutritional interventions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080742 | PMC |
| http://dx.doi.org/10.1016/j.tranon.2016.09.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modifications to the Geriatric Nutritional Risk Index Predicts Complications after Total Joint Arthroplasty.
J Arthroplasty
January 2025
Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, Virginia, 24016, United States of America; Department of Orthopaedic Surgery, Carilion Clinic Institute for Orthopaedics & Neurosciences, 2331 Franklin Road Southwest, Roanoke, Virginia, 24014, United States of America.
Background: Preoperative malnutrition is a known risk factor for postoperative complications following total joint arthroplasty (TJA), however, there is scant literature comparing which nutritional index is best at predicting these outcomes. The purpose of this study was to investigate the utility of the Maastricht Index (MI), Onodera's Prognostic Index (OPNI), the Geriatric Nutritional Risk Index (GNRI), and a novel, modified Geriatric Nutritional Risk Index (mGNRI) in predicting periprosthetic joint infection (PJI), wound complications (WC), readmission, and reoperation rates after TJA.
Methods: A single-center, retrospective cohort study was performed of patients who underwent primary TJA from January 2016 to December 2021.
Adolescents and Young Adults with Germline CDH1 Variants and the Risk of Overtreatment.
J Natl Cancer Inst
January 2025
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Background: Adolescents and young adults (AYA) with germline CDH1 variants are at risk of overtreatment when precancer lesions are detected with endoscopic screening. We characterize diffuse-type gastric cancer prevalence and survival in AYA managed with prophylactic total gastrectomy (PTG) or endoscopic surveillance.
Methods: Prospective cohort study of 188 individuals aged 39 and younger enrolled from January 27, 2017, to May 1, 2023.
Objective: Identification of patients with head-and-neck malignancies who are especially vulnerable to malnutrition is critical for optimizing outcomes. The objectives are; to correlate Bioelectrical-impendence-analysis (BIA) parameters with Subjective-Global-Assessment (SGA) scores, and determine the association of BIA parameters with common perioperative complications in patients undergoing head-and-neck surgery.
Study Design: Patients underwent formal SGA scoring and BIA preoperatively in a multidisciplinary allied health clinic.
Participation and Compliance in a Multimodal Prehabilitation Program for Colorectal Cancer (PACE): A Qualitative Study.
Patient Prefer Adherence
December 2024
Department of Surgery, Zuyderland Medical Center, Heerlen, 6419 PC, The Netherlands.
Purpose: Interest in prehabilitation, the preoperative enhancement of patients' condition, is rising in the surgical field. Challenging factors appear to be patients' motivation to participate in and their compliance with prehabilitation programs. The aim of this qualitative study was to study the real-life experience of prehabilitation by assessing the lived experience and perceptions of participants in a multimodal prehabilitation program and to explore factors that influence participation and compliance during prehabilitation.
View Article and Find Full Text PDFDeveloping a Nomogram-Based Prediction Model for Malnutrition Risk in Preoperative Elderly Patients with Hip Fracture.
J Multidiscip Healthc
December 2024
Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, People's Republic of China.
Objective: To evaluate the risk factors contributing to preoperative malnutrition in elderly patients with hip fractures.
Methods: The study retrospectively analysed clinical data from 182 elderly patients aged 60 years or older with hip fractures. Nutritional status was assessed according to the Global Leadership Initiative on Malnutrition diagnostic criteria, and risk factors associated with malnutrition were identified through univariate and logistic regression analyses.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!