Correlation of pretreatment proliferative activity of breast cancer with the response to cytotoxic chemotherapy.

J Natl Cancer Inst

Laboratory of Radiopathology and Physiopathology, Institut Curie, d'Ulm, Paris, France.

Published: September 1989

AI Article Synopsis

  • Most cytotoxic agents target actively dividing cells, prompting this study to connect S-phase fractions (SPF) measured via DNA histograms with tumor regression after chemotherapy.
  • The research involved 60 untreated premenopausal patients with noninflammatory tumors, evaluating DNA ploidy for all and SPF for 50 of these patients.
  • Results showed a strong link between SPF and tumor response, with patients having SPF of 10% or more demonstrating significant regression and six achieving complete responses, suggesting SPF may aid clinicians in treatment decisions.

Article Abstract

That most cytotoxic agents act specifically against actively proliferating cells is well-recognized. In this study, we attempted to correlate pretreatment S-phase fractions (SPF) measured on DNA histograms with regression of the tumor mass after the administration of neoadjuvant chemotherapy. Tumor cells were obtained from 60 previously untreated, premenopausal patients with no metastases and with noninflammatory disease by fine needle sampling without aspiration. We could evaluate DNA ploidy in all patients and SPF in 50 or 83% of them. Tumor responsiveness was significantly related to SPF. The 12 patients who had SPF of 10% or more showed demonstrable regression; six had complete responses. None of the other parameters tested, i.e., DNA ploidy, histopathologic grade, or hormone receptor content, correlated with response. We believe this information may prove valuable for clinicians as they make their decisions regarding patient therapy.

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http://dx.doi.org/10.1093/jnci/81.18.1383DOI Listing

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