AI Article Synopsis
- Cutaneous composite lymphomas, including aggressive PTCL-NOS and indolent FCBCL, have varied treatment approaches, with limited reports on the use of pegylated liposomal doxorubicin (PLE-DOXO).
- A 73-year-old male patient with this composite lymphoma experienced initial surgical removal of lesions, followed by successful treatment with PLE-DOXO, leading to a complete remission of skin lesions.
- After subsequent relapses and various treatments, the patient's overall survival lasted 28 months, highlighting the potential of PLE-DOXO as a viable systemic treatment option, though the benefits of further chemotherapy remain uncertain.
Article Abstract
Background: Cutaneous composite lymphomas are very rare. Their treatment depends upon the different contributing lymphoma entities. Peripheral T-cell lymphoma, not otherwise specified, (PTCL-NOS) represents an aggressive lymphoma subtype. Follicular cutaneous B-cell lymphoma (FCBCL) runs an indolent course. Treatment with pegylated liposomal encapsulated doxorubicin (PLE-DOXO) has yet not been reported in this entity.
Case Presentation: A 73-year-old male patient presented with 3 rapidly growing, painful nodules on his left leg. He was diagnosed as composite cutaneous lymphoma consisting of PTCL-NOS and FCBCL. All lesions had been surgically removed. Staging was unremarkable. After 4 months a relapse occurred with involvement of inguinal lymph nodes and systemic treatment with PEL-DOXO 20 mg/ m every 3 weeks was initiated. After 6 cycles PLE-DOXO, which were well tolerated without grade 3 or 4 toxicities, a mixed response was obtained with complete remission of cutaneous lesions.Lymph nodes were treated by radiotherapy. A second relapse occurred after 8 months and various polychemotherapy regimens were applied without remission. The overall survival was 28 months.
Conclusion: PEL-DOXO is a possible initial systemic treatment in case of PCTL-NOS. Whether polychemotherapy offers an advantage for survival remains questionable but further investigations are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089085 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000004796 | DOI Listing |
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