Now an associate professor at Swansea University, Julia Terry was a senior lecturer when she applied for a fellowship with the National Institute for Health and Care Excellence (NICE), and is convinced this was a key factor in her promotion.
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| http://dx.doi.org/10.7748/ns.31.9.38.s43 | DOI Listing |
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Birth defects reporting and the use of dydrogesterone: a disproportionality analysis from the World Health Organization pharmacovigilance database (VigiBase).
Hum Reprod Open
January 2025
Regional Center of Pharmacovigilance, Pharmacology Department, Cochin Hospital, AP-HP.Centre-Université Paris Cité, Paris, France.
Study Question: Is there an association between dydrogesterone exposure during early pregnancy and the reporting of birth defects?
Summary Answer: This observational analysis based on global safety data showed an increased reporting of birth defects, mainly hypospadias and congenital heart defects (CHD), in pregnancies exposed to dydrogesterone, especially when comparing to progesterone.
What Is Known Already: Intravaginal administration of progesterone is the standard of care to overcome luteal phase progesterone deficiency induced by ovarian stimulation in ART. In recent years, randomized controlled clinical trials demonstrated that oral dydrogesterone was non-inferior for pregnancy rate at 12 weeks of gestation and could be an alternative to micronized vaginal progesterone.
Post-Market Evidence for Cancer Medicines in Regulatory and Clinical Decision-Making: A Scoping Review.
Pharmacoepidemiol Drug Saf
January 2025
Charles Perkins Centre and School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Background: Cancer medicines usually have uncertain efficacy and safety profiles when they are first approved by medicines regulators because this evidence usually emerges post-market. Little is known about the extent to which post-market evidence is evaluated and integrated into evidence review processes in regulatory and clinical contexts.
Objectives: The objective of this scoping review is to examine the literature on how post-market evidence on benefits and harms is evaluated and integrated in regulatory decisions and guidance for clinical decision-making.
[Advances in pharmacological mechanism and toxicology of gambogic acid].
Zhongguo Zhong Yao Za Zhi
December 2024
Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu 610072,China Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China Chengdu 610072, China.
Gambogic acid, a caged xanthone compound derived from Garcinia, has been proven to be an important substance basis for the pharmacological effects of the plant. In recent years, it has received continuous attention due to its broad and significant pharmacological activities. Modern pharmacological investigations have demonstrated that gambogic acid endows various therapeutic effects such as anti-inflammatory, antioxidant, and anti-tumor activities, as well as benefits in retinopathy, organ protection, anti-microbial infection, bone protection, and neuropathic pain relief.
View Article and Find Full Text PDFInvestigating frontoparietal networks and activation in children with mathematics learning difficulties: Cases with different deficit profiles.
Eur J Neurosci
January 2025
National Institute of Education, Nanyang Technological University, Singapore.
Approximately 15%-20% of school-aged children suffer from mathematics learning difficulties (MLD). Most children with developmental dyscalculia (DD) or MLD also have comorbid cognitive deficits. Recent literature suggests that research should focus on uncovering the neural underpinnings of MLD across more inclusive samples, rather than limiting studies to pure cases of DD or MLD with highly stringent inclusion criteria.
View Article and Find Full Text PDFAssessing Bacteriological Profiles and Targeting Resistant Bacterial Superbugs to Develop an Antibiogram Aiding in Antibiotic Selection.
Cureus
December 2024
Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, IND.
Introduction The success of surgical procedures is becoming more threatened by the advent of multi-drug resistant (MDR) bacterial strains, sometimes known as superbugs. These resistant microorganisms frequently cause post-surgical infections, which raise morbidity, death, and medical expenses. With an emphasis on resistant strains, this seeks to create an antibiogram and a thorough microbiological profile of surgical infections in order to help choose the most effective antimicrobial therapy.
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