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Absence of Cysteine and Iron Chelation Induces Ferroptosis in Triple-Negative Breast Cancer Cells.
Breast Cancer (Auckl)
January 2025
Department of Pharmacy, Yonsei University, Incheon, South Korea.
Background: Ferroptosis is a recently studied form of programmed cell death characterized by lipid peroxides accumulation in the cells. This process occurs when a cell's antioxidant capacity is disturbed resulting in the inability of the cell to detoxify the toxic peroxides. Two major components that regulate ferroptosis are cysteine and iron.
View Article and Find Full Text PDFPredicting work ability impairment in post COVID-19 patients: a machine learning model based on clinical parameters.
Infection
January 2025
Department of Medicine II, LMU University Hospital, LMU Munich, Munich, Germany.
The Post COVID-19 condition (PCC) is a complex disease affecting health and everyday functioning. This is well reflected by a patient's inability to work (ITW). In this study, we aimed to investigate factors associated with ITW (1) and to design a machine learning-based model for predicting ITW (2) twelve months after baseline.
View Article and Find Full Text PDFEligibility Criteria of Randomized Clinical Trials in Critical Care Medicine.
JAMA Netw Open
January 2025
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Importance: Eligibility criteria for randomized clinical trials (RCTs) are designed to select clinically relevant patient populations. However, not all eligibility criteria are strongly justified, potentially excluding marginalized groups, and limiting the generalizability of trial findings.
Objective: To summarize and evaluate the justification of exclusion criteria in published RCTs in critical care medicine.
Association between psychophysically measured olfactory dysfunction and mental health status in long COVID patients.
Rhinology
January 2025
Department of Mental Health, Azienda Sanitaria Universitaria Giuliano Isontina - ASUGI, Trieste, Italy.
Background: Long COVID frequently presents with persistent olfactory dysfunction (OD), affecting both physical and psychological well-being. This study aims to evaluate the mental health consequences of OD in long COVID patients.
Methodology: A cross-sectional study involved 86 adult patients.
Field testing of recombinant subunit vaccines against in lambing ewes demonstrates a lack of efficacy in the face of a multi-species parasite challenge.
Front Parasitol
March 2024
Disease Control Department, Moredun Research Institute, Edinburgh, United Kingdom.
Introduction: We previously demonstrated efficacy of an 8-antigen recombinant subunit vaccine against a single species homologous challenge in lambs and in lambing ewes in pen trials. We subsequently demonstrated efficacy of a simplified, 2-antigen, version of this vaccine in lambs in pen trials. Here, we test both vaccines in lambing ewes in a field setting.
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