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Antifungal, Anticancer and Aminopeptidase Inhibitory Potential of a Phenazine Compound Produced by BSN307. | LitMetric

AI Article Synopsis

Article Abstract

A bioactive compound was purified from the culture medium of a new strain of BSN307 by solvent extraction followed by chromatographic techniques. This bioactive compound was identified to belong to phenazine class of compounds by MS, NMR and FTIR. The phenazine compound showed antifungal activity against , as well as by disc diffusion assay in addition to antioxidant potential as demonstrated by DPPH scavenging assay. The compound demonstrated selective cytotoxicity against cancer cell lines HeLa and MCF-7 where IC was achieved with 20 and 24 µg/mL respectively. At the same time no cytotoxicity was occurred in normal H9c2 cells. The bioactive found to be inhibitory to both leucine and proline aminopeptidases and thus revealed its potential as metalloenzyme inhibitor. This study, for the first time reports the production of phenazine class of compounds by lactic acid bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061690PMC
http://dx.doi.org/10.1007/s12088-016-0597-1DOI Listing

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