Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of T cells, yet these do not cause inflammation. The DCs that induce inflammatory T cells and the signals that drive this process remain unclear. Here, we demonstrate that small intestine DCs lacking the signaling attenuator A20 induce inflammatory T cells and that the signals perceived and antigen-presenting cell (APC) functions are unique for different DC subsets. Thus, although CD103CD11b DCs exclusively instruct IFNγ T cells, CD103CD11b DCs exclusively instruct IL-17 T cells. Surprisingly, APC functions of both DC subsets are upregulated in a MyD88-independent fashion. In contrast, CD103CD11b DCs instruct both IFNγ and IL-17 T cells, and only the IL-17-inducing APC functions require MyD88. In disease pathogenesis, both CD103CD11b and CD103CD11b DCs expand pathologic Th17 cells. Thus, in disease pathogenesis, specific DCs instruct specific inflammatory T cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123685 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2016.09.091 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of Dendritic Cells and Myeloid-Derived Suppressor Cells Expressing Major Histocompatibility Complex Class II in Secondary Lymphoid Organs in Systemic Lupus Erythematosus-Prone Mice.
Int J Mol Sci
December 2024
Millennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by self-antibody production and widespread inflammation affecting various body tissues. This disease is driven by the breakdown of immune tolerance, which promotes the activation of autoreactive B and T cells. A key feature of SLE is dysregulation in antigen presentation, where antigen-presenting cells (APCs) play a central role in perpetuating immune responses.
View Article and Find Full Text PDFFli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
Arthritis Res Ther
May 2021
Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background: Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclerosis (SSc). In this study, we investigated the contribution of Fli1 deficiency, a potential predisposing factor of SSc, to the phenotypical alteration of RALDH1-producing dermal DCs by using SSc model mice and SSc skin samples.
Methods: Bleomycin (BLM)-induced skin fibrosis was generated with Fli1 and wild-type mice.
Dendritic Cells of Mesenteric and Regional Lymph Nodes Contribute to O:3-Induced Reactive Arthritis in Mice.
J Immunol
April 2020
Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700 San Luis, Argentina; and
Dendritic cells (DCs) participate in the pathogenesis of several diseases. We investigated DCs and the connection between mucosa and joints in a murine model of O:3-induced reactive arthritis (ReA) in mice. DCs of mesenteric lymph nodes (MLN) and joint regional lymph nodes (RLN) were analyzed in and wild-type mice.
View Article and Find Full Text PDFIsolation of mononuclear phagocytes from the mouse gut.
Methods Enzymol
December 2020
Department of Immunology, University of Toronto, Toronto, ON, Canada. Electronic address:
The intestinal tract is home to trillions of microbes that make up the gut microbiota and is a major source of environmental antigens that can be derived from food, commensal microorganisms, and potential pathogens. Amidst this complex environment, myeloid cells, including macrophages (MPs) and dendritic cells (DCs), are key immunological sentinels that locally maintain both tissue and immune homeostasis. Recent research has revealed substantial functional and developmental heterogeneity within the intestinal DC and MP compartments, with evidence pointing to their regulation by the microbiota.
View Article and Find Full Text PDFEssential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt T cells.
Life Sci Alliance
January 2020
Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Article Synopsis
- - The activation of CD4 helper T (Th) cells relies on conventional dendritic cells (cDCs) presenting antigens, which influences the type of immune response initiated by the Th cells.
- - The study reveals that the absence of Runx/Cbfβ transcription factors during dendritic cell development leads to a decrease in specific cDC subtypes and negatively impacts the differentiation of Th17 and regulatory T cells.
- - Findings indicate that a Runx-binding enhancer is crucial for Th cells to respond to signals from cDCs, highlighting the importance of Runx/Cbfβ complexes in orchestrating type 3 immune responses.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!