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Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT.
Diagnostics (Basel)
January 2025
Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.
: Diffuse myocardial fibrosis and altered deformation are relevant prognostic factors in aortic stenosis (AS) patients. The aim of this exploratory study was to investigate the relationship between myocardial strain, and myocardial extracellular volume (ECV) in patients with severe AS with a photon-counting detector (PCD)-CT. : We retrospectively included 77 patients with severe AS undergoing PCD-CT imaging for transcatheter aortic valve replacement (TAVR) planning between January 2022 and May 2024 with a protocol including a non-contrast cardiac scan, an ECG-gated helical coronary CT angiography (CCTA), and a cardiac late enhancement scan.
View Article and Find Full Text PDFLeft Ventricular Assist Devices (LVADs) are a key treatment option for patients with advanced heart failure, but they carry a significant risk of thromboembolic complications. While improved LVAD design, and systemic anticoagulation regimen, have helped mitigate thromboembolic risks, ischemic stroke due to adverse thromboembolic events remains a major concern with current LVAD therapies. Improved understanding of embolic events, and embolus movement to the brain, is critical to develop techniques to minimize risks of occlusive embolic events such as a stroke after LVAD implantation.
View Article and Find Full Text PDFMultiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.
Acta Biomater
November 2024
Department of Mechanical and Aerospace Engineering, University of Kentucky, Lexington, KY, USA; Department of Surgery, University of Kentucky, Lexington, KY, USA. Electronic address:
The organization of myofibers and extra cellular matrix within the myocardium plays a significant role in defining cardiac function. When pathological events occur, such as myocardial infarction (MI), this organization can become disrupted, leading to degraded pumping performance. The current study proposes a multiscale finite element (FE) framework to determine realistic fiber distributions in the left ventricle (LV).
View Article and Find Full Text PDFEvaluation of double-chambered right ventricle flow using 4D flow MRI: right ventricular helical flow may not disappear even after surgical intervention.
Eur Heart J Imaging Methods Pract
September 2023
Department of Pediatrics, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Hokkaido 078-8510, Japan.
Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT.
Eur J Radiol Open
December 2024
Radiography & Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Objectives: This prospective study tested the diagnostic accuracy, and absolute agreement with MRI of a low-dose CT protocol for left ventricular ejection fraction (LVEF) measurement. Furthermore we assessed its potential for combining it with Chest-Abdomen-Pelvis CT (CAP-CT) for a one-stop examination.
Materials & Methods: Eighty-two patients underwent helical low-dose CT.
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