The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-016-3506-z | DOI Listing |
Publication Analysis
Top Keywords
brain injury
12
endotheliocytes hippocampal
8
hippocampal microvessels
8
expression transport
8
transport proteins
8
hypoxic brain
8
expression
5
perinatal brain
4
injury accompanied
4
accompanied disturbances
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!