The case of a 35-year-old primigravida with a 21-week intrauterine gestation and concurrent dysgerminoma of the ovary (stage Ic) is presented. A total hysterectomy with bilateral salpingo-oophorectomy was performed, followed by postoperative chemotherapy using cisplatin, bleomycin and vinblastine. The patient has done well since treatment, and is without evidence of recurrent disease 19 months later. Both radiation and chemotherapy are highly effective treatment modalities for dysgerminoma. For those patients with disease presenting in stages Ib, Ic, II and III who wish to maintain fertility, unilateral oophorectomy followed by combination chemotherapy may be curative and spare ovarian function.
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Sci Rep
October 2024
Department of Medical Oncology, King Fahad Specialist Hospital, Eastern Health Cluster, Dammam, Saudi Arabia.
Zhonghua Nan Ke Xue
July 2023
Department of Pathology, The People's Hospital of Jiangsu Province /The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Arch Pathol Lab Med
December 2024
From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer).
Context.—: Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid hormone production. The tissue distribution of StAR expression is limited to few human normal tissues.
View Article and Find Full Text PDFJ Intern Med
June 2024
Department of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University, Uppsala, Sweden.
Both ovarian and testicular germ cell tumors (GCTs) arise from the primordial germ cell and share many similarities. Both malignancies affect mainly young patients, show remarkable responsiveness to cisplatin-based therapy, and have an excellent prognosis, which also highlights the importance of minimizing long-term side effects. However, certain differences can be noted: The spreading of the disease differs, and the staging system and treatment recommendations are dissimilar.
View Article and Find Full Text PDFTheriogenology
March 2024
Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary. Electronic address:
Anti-Müllerian hormone (AMH) is a biomarker for the presence of gonadal tissue. Changes in serum AMH after gonadectomy are not well established, and its serum half-life is unknown in dogs. We measured serum AMH with a validated electro-chemiluminescent immunoassay in adult female (n = 12) and male (n = 7) dogs with normal gonads, as well as in dogs with gonadal pathology (ovarian remnant syndrome, ORS n = 3, testicular tumor [Leydig cell, Sertoli cell, seminoma] n = 3, unilateral abdominal cryptorchid n = 4) on the day of gonadectomy (D0), and on D3, D7, D14 (females and males), and D21, D28 (males only).
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