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| http://dx.doi.org/10.1002/jhm.2616 | DOI Listing |
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Purpose: Sickle cell disease (SCD) is an inherited red blood cell disease caused by a mutation in the gene encoding the β-subunit of adult hemoglobin that leads to hemolysis, anemia, vaso-occlusive crises (VOCs), morbidity, and mortality. This study provides a real-world assessment of the clinical burden and health care resource utilization (HCRU) associated with SCD with recurrent VOCs in England.
Methods: This retrospective study linked primary care records from the Clinical Practice Research Datalink database with secondary care records from the Hospital Episode Statistics database to identify patients with SCD with recurrent VOCs between July 1, 2008, and June 30, 2018.
Clinical outcomes following hospitalization for COVID-19 in patients with cardiac sarcoidosis in the United States: a propensity-matched analysis from national inpatient sample database from April 2020 to December 2021.
Ann Med Surg (Lond)
October 2024
Cardiac Sarcoidosis Services, Royal Brompton Hospital.
Article Synopsis
- Cardiac sarcoidosis (CS) is a serious condition that can lead to high rates of illness and death, and this study investigates its impact on patients hospitalized with COVID-19.
- The research analyzed data from over 2.5 million COVID-19 cases, finding that CS patients were generally younger and had more comorbidities compared to those without CS, and they experienced a higher rate of in-hospital cardiac arrest before matching.
- After matching, CS patients showed a significantly lower risk of acute kidney injury (AKI), but their rates of death, cardiac arrest, mechanical ventilation, and hospital stay length were similar to those without CS, indicating a need for further research on managing COVID-19 in CS patients.
A real-world study of hereditary angioedema patients due to C1 inhibitor deficiency treated with danazol in the Brazilian Public Health System.
Front Med (Lausanne)
September 2024
Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Article Synopsis
- Hereditary angioedema (HAE) is a rare disease affecting 1 in 67,000 people that can cause serious swelling and can be life-threatening if not treated.
- This study looked at patients in Brazil who are treated with a medicine called danazol from 2011 to 2021 to understand their health needs and how often they get hospitalized.
- The results showed that out of 799 patients, a significant number had attacks and many were hospitalized, highlighting the importance of better managing this condition.
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