AI Article Synopsis
- An efficient organocatalytic method was created for synthesizing α-hydroxyketones.
- Quinine-derived thiourea was used to catalyze the enantioselective Friedel-Crafts alkylation reactions.
- This process yielded chiral α-hydroxyketones in high amounts (up to 97% yield) and with excellent enantioselectivities (up to 99% ee).
Article Abstract
An efficient organocatalytic asymmetric synthesis of α-hydroxyketones has been developed. Quinine-derived thiourea catalyzed the enantioselective Friedel-Crafts alkylation of naphthols and activated phenols with aryl- and alkylglyoxal hydrates, providing the corresponding chiral α-hydroxyketones with high yields (up to 97%) and excellent enantioselectivities (up to 99% ee).
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| http://dx.doi.org/10.1021/acs.orglett.6b02893 | DOI Listing |
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