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Correlation of Emulsion Structure with Cellular Uptake Behavior of Encapsulated Bioactive Nutrients: Influence of Droplet Size and Interfacial Structure. | LitMetric

AI Article Synopsis

  • - This study used an in vitro Caco-2 cell culture assay to investigate how different emulsion structures affect the absorption of β-carotene, a nutrient important for health.
  • - Emulsions stabilized with whey protein isolate had the highest absorption of β-carotene (1.06 μg), significantly outperforming those stabilized with sodium caseinate (0.60 μg) and Tween 80 (0.20 μg), compared to free β-carotene (0.08 μg).
  • - Smaller droplet sizes in emulsions led to better cellular uptake of β-carotene, indicating that the way emulsions are structured can enhance the delivery and bioavailability of nutrients in the body.

Article Abstract

In this study, an in vitro Caco-2 cell culture assay was employed to evaluate the correlation between emulsion structure and cellular uptake of encapsulated β-carotene. After 4 h of incubation, an emulsion stabilized with whey protein isolate showed the highest intracellular accumulation of β-carotene (1.06 μg), followed by that stabilized with sodium caseinate (0.60 μg) and Tween 80 (0.20 μg), which are 13-, 7.5-, and 2.5-fold higher than that of free β-carotene (0.08 μg), respectively. Emulsions with small droplet size (239 ± 5 nm) showed a higher cellular uptake of β-carotene (1.56 μg) than emulsiond with large droplet size (489 ± 9 nm) (0.93 μg) (p < 0.01). The results suggested that delivery in an emulsion significantly improved the cellular uptake of β-carotene and thus potentially its bioavailability; uptake was closely correlated with the interfacial composition and droplet size of emulsions. The findings support the potential for achieving optimal controlled and targeted delivery of bioactive nutrients by structuring emulsions.

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Source
http://dx.doi.org/10.1021/acs.jafc.6b04136DOI Listing

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