HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals.

J Clin Transl Hepatol

Division of Infectious Diseases, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.

Published: September 2016

Therapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade, resulting in better control of infection and clinical outcomes; however, drug-drug interactions remain a significant hazard. Joint recommendations from the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America regarding drug-drug interactions between HIV antiretroviral agents and direct-acting antiviral agents for treatment of hepatitis C virus (HCV) infection are reviewed here. This review is oriented to facilitate appropriate selection of an antiviral therapy regimen for HCV infection based on the choice of antiretroviral therapy being administered and, if necessary, switching antiretroviral regimens.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075006PMC
http://dx.doi.org/10.14218/JCTH.2016.00026DOI Listing

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