Charophytes are the group of green algae whose ancestral lineage gave rise to land plants in what resulted in a profoundly transformative event in the natural history of the planet. Extant charophytes exhibit many features that are similar to those found in land plants and their relatively simple phenotypes make them efficacious organisms for the study of many fundamental biological phenomena. Several taxa including , and are valuable model organisms for the study of cell biology, development, physiology and ecology of plants. New and rapidly expanding molecular studies are increasing the use of charophytes that in turn, will dramatically enhance our understanding of the evolution of plants and the adaptations that allowed for survival on land. The series on "Charophytes" provides an assortment of new research reports and reviews on charophytes and their emerging significance as model plants.
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http://dx.doi.org/10.3389/fpls.2016.01470 | DOI Listing |
Microbiology (Reading)
January 2025
AIMES-Center for the Advancement of Integrated Medical and Engineering Sciences, Karolinska Institutet and KTH Royal Institute of Technology, SE-171 77 Stockholm, Sweden.
Human skin is our primary physical barrier and largest immune organ, and it also hosts a protective microbiota. Staphylococci are prominent members of the skin microbiota, including the ubiquitous coagulase-negative staphylococci (CoNS). The coagulase-positive is found as part of the microbiota, but it poses clinical concern due to its potential pathogenicity and antibiotic resistance.
View Article and Find Full Text PDFCrit Care Explor
February 2025
Division of Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Importance: While corticosteroid administration in septic shock has been shown to result in faster shock reversal and lower short-term mortality, the role of corticosteroids in the management of cardiogenic shock (CS) remains unexplored.
Objectives: Determine the impact of corticosteroid administration on 90-day mortality (primary outcome) in patients admitted to a critical care unit with CS.
Design, Setting, And Participants: In this retrospective cohort study, we used the critical care database of Medical Information Mart for Intensive Care-IV, and included all adult patients diagnosed with CS excluding repeated admissions, patients with adrenal insufficiency, those receiving baseline corticosteroids, and those requiring extracorporeal life support.
Fish Physiol Biochem
January 2025
Centro Tlaxcala de Biología de La Conducta, Universidad Autónoma de Tlaxcala, 90070, Tlaxcala, Mexico.
Trophic factors, such as neurotrophins, are fundamental for cellular processes including differentiation, growth, survival, and regeneration. These molecules exhibit significant morphological and phylogenetic conservation throughout the animal kingdom, indicating conserved functions. In fish, the oldest and most diverse group of vertebrates, neurotrophins, and their receptors play pivotal roles not only within the central nervous system but also in various peripheral tissues.
View Article and Find Full Text PDFEJNMMI Radiopharm Chem
January 2025
Department of Advanced Nuclear Medicine Sciences, Institute of Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
Background: 4-(4-Cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (remodelin) is a potent N-acetyltransferase 10 (NAT10) inhibitor. This compound inhibits tumors and weakens tumor resistance to antitumor drugs. Moreover, remodelin has been found to enhance healthspan in an animal model of the human accelerated ageing syndrome.
View Article and Find Full Text PDFJ Biol Inorg Chem
January 2025
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Iron-sulfur proteins perform a wide variety of reactions central to the metabolisms of all living organisms. Foundational to their reaction chemistry are the rich electronic structures of their constituent Fe-S clusters, which differ in important ways from the active sites of mononuclear Fe enzymes. In this perspective, we summarize the essential electronic structure features that make Fe-S clusters unique, and point to the need for studies aimed at understanding the electronic basis for their reactivity under physiological conditions.
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