Cherenkov Luminescence Imaging (CLI) is a new method to image radioactive therapeutic and diagnostic agents, primarily in preclinical studies. This study used Geant4 and Python to generate the predicted Cherenkov light production as a function of time for a set of isotopic chains of interest for targeted alpha therapy: Ra, Pb, and Tb. All are shown to produce substantial Cherenkov light, though time delays between initial decays and the production of Cherenkov light requires caution in interpreting CLI.
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School of Health Sciences, Department of Radiological Technology, Nagoya University, Japan.
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Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, United States of America.
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