AI Article Synopsis
- Iron overload is a major concern for leukemia patients and those who have had allogeneic hematopoietic stem cell transplantation (alloHSCT), impacting survival rates.
- Researchers analyzed the bone marrow iron scores (BMIS) of 125 patients to understand pre-transplant iron levels and their effects.
- Results showed that higher BMIS was linked to poorer overall survival and disease-free survival, suggesting BMIS can be used for risk assessment in alloHSCT patients.
Article Abstract
Background: Iron overload is one of the most significant problems as a leading cause of death in patients with leukemia and those who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT).
Methods: In the current study, we retrospectively evaluated the bone marrow iron scores (BMIS) in patients who underwent alloHSCT (n = 125). The first available bone marrow biopsy specimens prior to the alloHSCT procedure or date of hospitalization (control group) were assessed in a blinded fashion using a standardized scoring system.
Results: A total of 125 patients were enrolled in the study. Seventy-six (60.8%) of the patients were male, and 49 (39.2%) were female. The median level of pre-transplant serum ferritin was 1023.00 ng/mL (range, 393.80-1627.50 ng/mL). The majority of the patients were diagnosed with acute leukemia (83; 66.4%) and lymphomas (20; 16.0%). The median time for neutrophil engraftment was 14.00 days (range, 13.00-16.00 days) and 11.00 days (range, 10.00-14.00 days) for platelet engraftment. The peri-transplant mortality was similar to international mortality rates (3; 2.4%). The overall survival and disease-free survival were strongly correlated with the degree of BMIS, and both were significantly poorer in patients with high bone marrow iron content (P < .001 and P = .012, respectively).
Conclusion: The validation of BMIS for risk stratification in patients who undergo alloHSCT may predict posttransplant outcomes.
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| http://dx.doi.org/10.1016/j.clml.2016.08.002 | DOI Listing |
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