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Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. | LitMetric

AI Article Synopsis

  • Emodin, an anti-inflammatory anthraquinone from a Chinese herb, was tested for its protective effects on jejunum injury in a sepsis model created in male Wistar rats.
  • The study revealed that emodin reduces inflammation markers (IL-6, TNF-α, procalcitonin) and apoptosis levels in the jejunum tissue, suggesting less damage due to sepsis.
  • Emodin activated the JAK1/STAT3 signaling pathway and improved the balance of Bcl-2 and Bax proteins, which helps protect the jejunum from sepsis-related injury.

Article Abstract

Emodin is an anthraquinone derived from Chinese herb that exerts anti-inflammation effects. This study aimed to investigate whether emodin provides the protection for jejunum injury by inhibiting inflammation. We established a model of sepsis caused by cecal ligation and puncture. Forty-eight male Wistar rats were divided into four groups (n=12). Jejunum injury was assessed by pathological examination. The activity of pJAK1/pSTAT3 and protein levels of Bcl-2 and Bax were detected by Western blot analysis. Inflammatory factors IL-6, TNF-α and procalcitonin were detected by ELISA. Apoptosis was detected by TUNEL. We found that emodin alleviated jejunum damage and apoptosis induced by sepsis and decreased the levels of IL-6, TNF-α and procalcitonin in septic rats. Furthermore, we observed that emodin increased the levels of pJAK1 and of pSTAT3, which were decreased in rats with sepsis. In addition, emodin enhanced the expression of Bcl-2 which was downregulated by sepsis and decreased the expression of Bax which was upregulated by sepsis. In conclusion, these results indicate that emodin suppresses inflammatory response induced by sepsis. Emodin activates JAK1/STAT3 signaling pathway and regulates Bcl-2 and Bax expression to protect the jejunum in rats with sepsis.

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Source
http://dx.doi.org/10.1016/j.biopha.2016.10.031DOI Listing

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