Conclusion: Gastric type H,K-ATPase in the vestibular end organs may be of importance for K circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac.
Objective: To analyze the expression of gastric-type H,K-ATPase in normal mouse vestibular end organs.
Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H,K-ATPase α and β in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry.
Results: In the vestibular end organs, H,K-ATPase α and β were almost identical. H,K-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.
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