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Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats. | LitMetric

AI Article Synopsis

  • Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant public health challenge as there are few effective treatments available for these infections, which are mainly found in humans and environmental samples, with limited cases reported in pets.* -
  • This research highlights the isolation of a carbapenemase-producing strain of Salmonella enterica Typhimurium, identified in a sick cat and three others from an animal shelter, showing genetic similarities to CRE found in human isolates from China.* -
  • The study emphasizes the potential risk of CRE spreading among animals and humans, suggesting that infections in companion animals can contribute to the wider problem of antibiotic resistance.*

Article Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying bla was identified from a systemically unwell (index) cat and three additional cats at an animal shelter. All isolates were identical and belonged to ST19. Genome sequencing revealed the acquisition of a multidrug-resistant IncHI2 plasmid (pIMP4-SEM1) that encoded resistance to nine antimicrobial classes including carbapenems and carried the bla-qacG-aacA4-catB3 cassette array. The plasmid also encoded resistance to arsenic (MIC-150 mM). Comparative analysis revealed that the plasmid pIMP4-SEM1 showed greatest similarity to two bla carrying IncHI2 plasmids from Enterobacter spp. isolated from humans in China. This is the first report of CRE carrying a bla gene causing a clinical infection in a companion animal, with presumed nosocomial spread. This study illustrates the broader community risk entailed in escalating CRE transmission within a zoonotic species such as Salmonella, and in a cycle that encompasses humans, animals and the environment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073282PMC
http://dx.doi.org/10.1038/srep35527DOI Listing

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