AI Article Synopsis
- Immunization strategies targeting nonpregnant adults may reduce the risk of invasive group B Streptococcus (GBS) infections, although the immune response in adults has not been fully explored.
- A study conducted in Houston identified 102 adult cases of GBS bacteremia, highlighting that a significant portion had related infections like skin/soft tissue infections and bacteremia without a clear source.
- The findings showed that the majority of GBS strains expressed specific capsular polysaccharides and pili, and an increase in related antibodies during recovery indicates the potential for developing a vaccine to prevent GBS bacteremia in adults.
Article Abstract
Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis. CPS-specific IgG was determined by ELISA and pilus-specific IgG by multiplex immunoassay. CPS types were Ia (24.5%), Ib (12.7%), II (9.8%), III (16.7%), IV (13.7%), and V (12.7%); 9.8% were nontypeable by serologic methods. Pili, expressed by 89%, were most often PI-2a. CPS and pilus-specific IgG increased during convalescence among patients with strains expressing CPS or PI. All GBS expressed CPS or PI; 79% expressed both. Increased antibodies to CPS and PI during recovery suggests that GBS bacteremia in adults is potentially vaccine preventable.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088039 | PMC |
| http://dx.doi.org/10.3201/eid2211.160914 | DOI Listing |
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