The transitions, i.e. time intervals between two different behavioural states, were studied in 10 healthy and 10 growth retarded fetuses (IUGR) in near term pregnancies. In healthy fetuses, transitions usually lasted less than 3 min whereas IUGR fetuses showed a longer duration when compared to healthy fetuses. Moreover, a significant trend in the change of state variables (fetal heart rate, fetal eye movements and fetal gross body movements) was evident in healthy fetuses: fetal heart rate was the first variable to change in transitions from 1F to 2F and the last variable to change in transitions from 2F to 1F. On the other hand IUGR fetuses showed a random sequence in order of change. These findings were substantiated by the intraindividual consistency evidenced in repeated recordings. In conclusion the analysis of transitions differentiates between healthy fetuses and those affected by IUGR.
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http://dx.doi.org/10.1016/0378-3782(89)90076-5 | DOI Listing |
J Perinat Med
January 2025
Tufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Objectives: Maternal obesity increases a child's risk of neurodevelopmental impairment. However, little is known about the impact of maternal obesity on fetal brain development.
Methods: We prospectively recruited 20 healthy pregnant women across the range of pre-pregnancy or first-trimester body mass index (BMI) and performed fetal brain magnetic resonance imaging (MRI) of their healthy singleton fetuses.
Case Rep Cardiol
December 2024
Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Aortic dissection (AoD) is a rare fatal condition in which tearing in the intima causes a false channel in the aorta and can lead to rupture. AoD is classified as the DeBakey classification (Types I, II, III) and Stanford classification (Types A and B). Women with underlying risk factors such as hypertension, smoking, bicuspid aortic valve, and connective tissue disorders are at risk for pregnancy-related AoD.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian, China.
Amniotic fluid (AF)-derived exosomal miRNA have been explored as potential contributors to the pathogenesis of Tetralogy of Fallot (TOF). This study aimed to investigate the expression profiles of AF-derived exosomal miRNAs and their potential contribution to TOF development. Exosomes were isolated from AF samples obtained from pregnant women carrying fetuses diagnosed with TOF.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, Madrid, Community of Madrid, Spain.
J Pediatr Surg
December 2024
Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: We sought to determine whether transamniotic stem cell therapy (TRASCET) could be a viable alternative for the fetal administration of genetically modified hematopoietic stem cells (HSCs) carrying a human hemoglobin subunit beta gene (hHBB) in a healthy syngeneic rat model.
Methods: Time-dated pregnant Lewis dams underwent volume-matched intra-amniotic injections in all their fetuses (n = 61) of a suspension of donor HSCs genetically modified with either both a hHBB gene and a firefly luciferase reporter gene (n = 42) or the firefly luciferase reporter gene alone to control for HBB-derived protein interspecies homology (n = 19) on gestational day 17 (E17; term = E21). Donor HSCs consisted of syngeneic cells phenotyped by flow cytometry with successful hHBB transduction confirmed by ELISA prior to administration in vivo.
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