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Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment.
Front Chem
January 2025
African Society for Bioinformatics and Computational Biology, Cape Town, South Africa.
Introduction: Treatment of type 2 diabetes (T2D) remains a significant challenge because of its multifactorial nature and complex metabolic pathways. There is growing interest in finding new therapeutic targets that could lead to safer and more effective treatment options. Takeda G protein-coupled receptor 5 (TGR5) is a promising antidiabetic target that plays a key role in metabolic regulation, especially in glucose homeostasis and energy expenditure.
View Article and Find Full Text PDFExperiences and opinions of adults with type 1 diabetes on the android-based open-source closed-loop system in China: a qualitative study.
BMJ Open
January 2025
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, Guangdong, China
Objective: As an emerging technology, Android-based open-source closed-loop system also called Android Artificial Pancreas System (AAPS), has been increasingly validated by evidence for its effectiveness in improving glycaemic outcomes, positioning it as a crucial option for managing type 1 diabetes (T1D). However, there are still only a few studies examining the experiences of using AAPS, and relevant qualitative studies have not been conducted in Asia so far. This study aimed to explore the experiences and opinions of adult patients with T1D on the AAPS.
View Article and Find Full Text PDFDo continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study.
BMJ Open
January 2025
Diabetes Care Unit, Caen University Hospital, Caen cedex 09, France.
Introduction: Glycated haemoglobin (HbA1c) is currently the gold standard for assessing glycaemic control in diabetes, given the established relationship with microvascular and macrovascular complications in this condition. However, HbA1c is affected by non-glycaemic factors, while also failing to provide data on hypoglycaemic exposure and glucose variability, which are associated with adverse vascular outcomes. Continuous glucose monitoring (CGM)-derived glucose metrics provide a more comprehensive assessment of glycaemia, but their role in predicting future vascular complications remains unclear.
View Article and Find Full Text PDFRationale and strategies for improving glycaemic control in diabetic patients undergoing cardiac surgery: a narrative review.
J Thorac Dis
November 2024
Department of Cardiothoracic Surgery, Royal Papworth Hospital, Cambridge, UK.
Background And Objective: The global prevalence of diabetes mellitus has markedly risen in recent years. Consequently, there has been a rise in the number of patients with diabetes undergoing cardiac surgery. Despite the existence of national and international guidelines to improve surgical outcomes in patients with diabetes, perioperative diabetes management optimisation remains inadequate resulting in these patients experiencing increased rates of surgical morbidity and mortality.
View Article and Find Full Text PDFThe clinical importance of measuring glycaemic variability: Utilising new metrics to optimise glycaemic control.
Diabetes Obes Metab
December 2024
LIGHT Laboratories, Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Article Synopsis
- * This review focuses on short-term GV and its potential impact on both microvascular and macrovascular complications, acknowledging that its role in vascular issues is not entirely clear due to varying findings in different populations.
- * Future research is needed to clarify the independent effects of GV versus other factors like hypoglycaemia, with the goal of establishing proper GV targets for optimizing diabetes management and reducing complications.
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