[This corrects the article DOI: 10.1371/journal.pone.0142078.].

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072672PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165350PLOS

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Article Synopsis
  • Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death and disability in newborns, and caffeine has shown promise in mitigating its effects.
  • In a neonatal rat model, caffeine administration post-injury reduced brain damage and inflammation compared to controls, highlighting its potential benefits.
  • The study found that caffeine influences the AMPK/mTOR pathway, suggesting that targeting this pathway could enhance neuroprotection and improve outcomes for HIE, especially in regions lacking sufficient resources for treatment.
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Objective: Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body mass index (BMI), and behavior as children enter adolescence.

Method: Longitudinal data and caregiver-reported prenatal caffeine exposure were obtained from the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which recruited 11,875 children aged 9-11 years at baseline from 21 sites across the United States starting June 1, 2016.

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This study presents a new method for simultaneously quantifying a complex anti-migraine formulation containing five components (ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine) using UV spectrophotometry and chemometric models. The formulation presents analytical challenges due to the wide variation in component concentrations (ERG: PRO: CAF: CAM: MEC ratio of 0.075:20:8:5:4) and highly overlapping UV spectra.

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