This is part 2 of a three-part series designed to provide clinicians with a working knowledge of the use of herbal supplements for health and disease states. Part 2 of the series focuses on the efficacy of herbal supplements used in the treatment of common chronic conditions.
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| http://dx.doi.org/10.1097/01.NPR.0000502793.50737.2f | DOI Listing |
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Quercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet.
Am J Reprod Immunol
January 2025
Laboratory of Molecular Genetics and Experimentation in Animal Reproduction, University of Western São Paulo (Unoeste), Presidente Prudente, São Paulo, Brazil.
Problem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.
View Article and Find Full Text PDFAssessing the Impact of Early Nutritional Intervention on Pediatric Celiac Disease Management: A Prospective Cohort Study.
Cureus
December 2024
Medicine, Basic Health Unit 155/wb, Vehari, PAK.
Background: Celiac disease is a chronic autoimmune condition requiring lifelong adherence to a gluten-free diet, particularly in children, to prevent nutritional deficiencies and developmental delays.
Objective: The objective of study was to evaluate the effects of early nutritional intervention on the management and health outcomes of children diagnosed with celiac disease.
Methodology: A prospective, longitudinal cohort study was conducted over two years (July 2019-July 2021).
Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota.
Front Microbiol
January 2025
School of Life Sciences, Anhui Medical University, Hefei, Anhui, China.
Background: Obesity and high fasting blood glucose (FBG) resulting from high-fat diets (HFDs) have emerged as significant public health concerns, garnering increasing attention. Recently, gut microbiota has been linked with metabolic diseases such as type 2 diabetes (T2DM), and its mediating role in dietary supplements has been confirmed. Seeking various dietary supplements to lose body weight (BW) and decrease FBG and explaining the underlying mechanism have become the research hotspots in T2DM studies.
View Article and Find Full Text PDFThe benefits and harms of oral iron supplementation in non-anaemic pregnant women: a systematic review and meta-analysis.
Fam Pract
January 2025
Nuffield Department of Primary Care Health Sciences, Centre for Evidence Based Medicine, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, United Kingdom.
Background: Iron deficiency during pregnancy poses a significant risk to both maternal and foetal health. Current international guidelines provide discrepant advice on antenatal iron supplementation for non-anaemic women.
Objective: We aimed to quantify the benefits and harms of routine antenatal supplementation in non-anaemic women.
Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies.
Microbiome
January 2025
Department of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.
Background: The human gut microbiome strongly influences host metabolism by fermenting dietary components into metabolites that signal to the host. Our previous work has shown that Intestinimonas butyriciproducens is a prevalent commensal bacterium with the unique ability to convert dietary fructoselysine to butyrate, a well-known signaling molecule with proven health benefits. Dietary fructoselysine is an abundant Amadori product formed in foods during thermal treatment and is part of foods rich in dietary advanced glycation end products which have been associated with cardiometabolic disease.
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