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Iristectorin A Ameliorates Cisplatin-Induced Hepatorenal Injury in Mice Through Modulation of the Nrf2/HO-1 Signaling Pathway.
J Biochem Mol Toxicol
January 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Cisplatin (CIS) is a chemotherapeutic agent frequently used in cancer treatment. However, depending on the dosage and duration of use, CIS can lead to hepatotoxicity and nephrotoxicity. Iristectorin A (IRIS), a natural flavonoid, has been found to exhibit antioxidant and protective effects.
View Article and Find Full Text PDFEffects of dietary hydroxy-cinnamic acid derivatives on growth, muscle, and intestinal parameters of Tilapia (Oreochromis niloticus).
Fish Physiol Biochem
January 2025
Key Laboratory for Animal Nutrition and Feed Science of Hubei Province, Wuhan Polytechnic University, Wuhan, 430000, China.
Hydroxycinnamic acid derivatives are a class of phenolic acid compounds, including sinapic acid, ferulic acid, and caffeic acid, which are widely found in plants. This experiment was conducted to study the effects of hydroxycinnamic acid derivatives (sinapic acid, ferulic acid, and caffeic acid) on the growth performance, muscle physical parameters, and intestinal morphology of tilapia. A total of 320 tilapia fingerlings (9.
View Article and Find Full Text PDFEffect of the Deubiquitinating Peptidase 7 (USP7) on Hepatitis B Virus (HBV) Replication and the Antiviral Efficacy of Entecavir (ETV).
Mol Biotechnol
December 2024
School of Public Health, North China University of Science of Technology, Tangshan, 062310, Hebei, China.
Hepatitis B is a viral infection of the liver caused by the hepatitis B virus (HBV). Entecavir (ETV) is considered the primary therapeutic option for HBV treatment, primarily functioning by inhibiting HBV replication. Ubiquitin-specific peptidase 7 (USP7), a deubiquitinating enzyme, plays a crucial role in regulating DNA repair mechanisms.
View Article and Find Full Text PDFAnalysis of the diagnostic effect of F-FDG PET/CT in IIM patients and its relationship with disease severity.
Hell J Nucl Med
December 2024
Department of Neurology, Taihe Hospital of Hubei University of Medicine, Shiyan, China.
Objective: To analyze the diagnostic effect of fluorine-18-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with idiopathic inflammatory myopathies (IIM) and its relationship with disease severity.
Subjects And Methods: A retrospective analysis was conducted on the clinical and imaging data of 31 IIM patients treated in our hospital from April 2020 to April 2024, who were included in the lesion group. Additionally, 30 patients without muscle disease during the same period were selected as the control group.
Lasia spinosa Stem Aqueous Extract Potentiates Antidiabetic Effects Exhibiting Antioxidant Genes Upregulation and DNA-Damage Protection.
Chem Biodivers
December 2024
Department of Biochemistry & Molecular Biology, University of Chittagong, Chittagong, Bangladesh.
This research elucidated the hypoglycemic effect correlated with DNA-protective and antioxidative activity of Lasia spinosa stem aqueous extract (LSSAE) using streptozotocin-induced type 2 diabetic rat models. LSSAE, characterized by phytochemical screening, gas chromatography-mass spectroscopy (GC-MS), and FTIR analyses, was investigated for its DNA-protective activity by exposing PBR322 plasmid DNA to Fenton's reagents. Long Evans rats, treated by LSSAE, were found to be improved for body weight, fasting blood glucose level, and oral glucose load.
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