Cavitation plays a significant role in the efficacy of stone comminution during shockwave lithotripsy (SWL). Although cavitation on the surface of urinary stones helps to improve fragmentation, cavitation bubbles along the propagation path may shield or block subsequent shockwaves (SWs) and potentially induce collateral tissue damage. Previous in vitro work has shown that applying low-amplitude acoustic waves after each SW can force bubbles to consolidate and enhance SWL efficacy. In this study, the feasibility of applying acoustic bubble coalescence (ABC) in vivo was tested. Model stones were percutaneously implanted and treated with 2500 lithotripsy SWs at 120 SW/minute with or without ABC. Comparing the results of stone comminution, a significant improvement was observed in the stone fragmentation process when ABC was used. Without ABC, only 25% of the mass of the stone was fragmented to particles <2 mm in size. With ABC, 75% of the mass was fragmented to particles <2 mm in size. These results suggest that ABC can reduce the shielding effect of residual bubble nuclei, resulting in a more efficient SWL treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144866 | PMC |
| http://dx.doi.org/10.1089/end.2016.0407 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Harnessing magnetism: evaluation of safety, tolerance and feasibility of magnetic kidney stone retrieval in vivo in porcine models.
Urolithiasis
December 2024
Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstr. 6, 8010, Graz, Austria.
The primary objective of urolithiasis therapy is complete stone removal and highest stone-clearance rates possible to minimize recurrence. A novel approach that employs a magnetic suspension and a magnetic probe for the passive collection and removal of small residual fragments was developed. This study assessed the feasibility of this system in porcine models.
View Article and Find Full Text PDFCavitation cloud formation and surface damage of a model stone in a high-intensity focused ultrasound field.
Ultrason Sonochem
January 2024
Institute of Fluid Dynamics, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, Zurich 8092, Switzerland. Electronic address:
This work investigates the fundamental role of cavitation bubble clouds in stone comminution by focused ultrasound. The fragmentation of stones by ultrasound has applications in medical lithotripsy for the comminution of kidney stones or gall stones, where their fragmentation is believed to result from the high acoustic wave energy as well as the formation of cavitation. Cavitation is known to contribute to erosion and to cause damage away from the target, yet the exact contribution and mechanisms of cavitation remain currently unclear.
View Article and Find Full Text PDFPhotonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution.
Nano Lett
July 2023
Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland Ohio 44195, United States.
Near-infrared activated nanomaterials have been reported for biomedical applications ranging from photothermal tumor destruction to biofilm eradication and energy-gated drug delivery. However, the focus so far has been on soft tissues, and little is known about energy delivery to hard tissues, which have thousand-fold higher mechanical strength. We present photonic lithotripsy with carbon and gold nanomaterials for fragmenting human kidney stones.
View Article and Find Full Text PDFHigh-frequency shock wave lithotripsy: stone comminution and evaluation of renal parenchyma injury in a porcine ex-vivo model.
World J Urol
July 2023
Department for Urology and Andrology, Danube Private University, Krems, Austria.
Article Synopsis
- A new method using electrohydraulic high-frequency shock waves was tested for breaking down stones in a study involving both stones and pig kidneys, evaluating its effectiveness and safety.
- The experiments revealed no clear link between the number of shock waves, energy applied, and the success in fragmenting stones or causing kidney injuries, suggesting the technical parameters used had little impact.
- Ultimately, the high-frequency method demonstrated the ability to create small stone fragments quickly, with kidney damage levels similar to those observed in traditional methods using lower frequencies.
A Multi-Spark Electrohydraulic Shock Wave Generator with Adjustable Pressure Field Distribution and Beam Steering Capability.
Front Urol
March 2023
Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA.
Background And Objective: All clinical shock wave lithotripters produce an axisymmetric acoustic field without accounting for the anatomic features of the kidney or respiratory motion of the patient. This work presents a steerable and adjustable focusing electrohydraulic (SAFE) shock wave generator design with variable beam size and shape.
Materials And Methods: 90 electrohydraulic transducers are mounted concentrically on a spherical basin with adjustable connection to individual transducers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!