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Candidiasis in Pregnancy: Relevant Aspects of the Pathology for the Mother and the Fetus and Therapeutic Strategies.
Trop Med Infect Dis
May 2024
Division of Pediatrics and Neonatology, Department of Maternal, Neonatal and Infant Medicine, University Hospital "Degli Infermi", 13875 Ponderano, Italy.
Vulvovaginal candidiasis (VVC) is a common condition that can lead to significant discomfort, affecting approximately 70-75% of women at least once in their lives. During pregnancy, the prevalence of VVC is estimated to be around 20%, peaking at about 30% in the third trimester, with a number of specific risk factors predisposing to yeast infection being identified and needing elucidation. This review aims to provide updated knowledge on candidiasis during pregnancy, addressing risk factors and maternal and neonatal outcomes, as well as discussing optimal therapeutic strategies to safeguard mothers and newborns.
View Article and Find Full Text PDFIntra-amniotic Infection Treated With Liposomal Amphotericin B With a Successful Neonatal Outcome.
Open Forum Infect Dis
February 2024
Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Intra-amniotic infection with species is an uncommon but severe condition with high fetal morbimortality and no established clinical guidelines for its management. We report a intra-amniotic infection diagnosed in a 25-week pregnant woman, successfully treated with high-dose liposomal amphotericin B. Pregnancy was prolonged until 30 weeks, and despite persistently positive cultures in amniotic fluid, a healthy newborn was delivered without evidence of systemic infection.
View Article and Find Full Text PDFMaternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications.
Children (Basel)
May 2023
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
As the leading cause of neonatal morbidity and mortality, preterm birth is recognized as a major public health concern around the world. The purpose of this review is to analyze the connection between infections and premature birth. Spontaneous preterm birth is commonly associated with intrauterine infection/inflammation.
View Article and Find Full Text PDFNext-generation sequencing-based detection of in the gastric fluid of neonates with respiratory distress and chorioamnionitis.
J Matern Fetal Neonatal Med
December 2023
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Background: Respiratory distress is common in neonates admitted to neonatal intensive care units. Additionally, infectious diseases such as intrauterine infections or vertical transmission are important underlying causes of respiratory failure. However, pathogens often cannot be identified in neonates, and there are many cases in which antibacterial drugs are empirically administered.
View Article and Find Full Text PDFMultimodal Management of Cervical Insufficiency Complicated by Intra-amniotic Candida albicans Infection.
Am J Perinatol
May 2024
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Introduction: Bacteria are the most common pathogens implicated in ascending infections in patients with cervical insufficiency. However, is a rare and serious cause of intra-amniotic infection that should be considered on the differential diagnosis. Upon diagnosis following cerclage placement, patients are generally advised to undergo immediate cerclage removal and discontinuation of the pregnancy due to the high risk of maternal and fetal morbidity.
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