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http://dx.doi.org/10.1016/j.bpj.2016.09.015 | DOI Listing |
Anal Chem
January 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
The development of a sensory signal amplification approach is very crucial for rapid and precise detection of aflatoxin B (AFB). However, such approaches remain scarce due to the weak interactions between AFB and the sensing probes. Herein, the first example of a dual-excitation fluorescent platform for antibody-free AFB detection is reported, which is assembled by an ordered π-π stack of cationic perylene derivative (PTHA) and tris(2,2'-bipyridine)ruthenium(II) [Ru(bpy)].
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang, Henan 471023, People's Republic of China.
The sensitive and selective identification of nitroaromatic explosives and industrially ubiquitous nitrates, which are harmful to the environment, is crucial from the viewpoints of security and environmental remediation. New multifunctional fluorescent porous materials that can sense nitro-explosives and nitrates are under continuous development. To this end, this study synthesizes 3,10,15-/-3,10,16-tribromotrinaphtho[3.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou 730000, China.
Mercury ions (Hg) have been found to disrupt the body's antioxidant defense mechanisms, leading to oxidative stress and physiological dysfunction. Early diagnosis and real-time monitoring of Hg fluctuations in organ damage are crucial but limited due to the lack of noninvasive and deep tissue imaging probes. Herein, a Hg-triggered targeted and NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for real-time monitoring Hg fluctuations in Hg-induced acute liver and kidney injury mice.
View Article and Find Full Text PDFRSC Chem Biol
December 2024
Department of Biochemistry, University of Colorado Boulder CO 80309-0596 USA +1 303 492 5894 +1 303 735 2159 +1 303 492 1945.
Linkers in chemical biology provide more than just connectivity between molecules; their intrinsic properties can be harnessed to enhance the stability and functionality of chemical probes. In this study, we explored the incorporation of a peptide nucleic acid (PNA)-based linker into RNA-targeting probes to improve their affinity and specificity. By integrating a PNA linker into a small molecule probe of the Riboglow platform, we enabled dual binding events: cobalamin (Cbl)-RNA structure-based recognition and sequence-specific PNA-RNA interaction.
View Article and Find Full Text PDFRSC Adv
January 2025
Nanobiosensing and Microfluidic Point-of-Care Testing, Key Laboratory of Luzhou, Department of Clinical Laboratory, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University Luzhou Sichuan 646000 PR China
Accurate, rapid, and multiplex SNP analysis holds significant clinical value. However, the inevitable nucleic acid extraction, involving centrifugation, heating, and magnetic separation, is often time-consuming. In this study, direct blood PCR was combined with dual-labelled probe-mediated melting curves to identify SNPs corresponding to MTHFR (C677T, rs#1801133 and A1298C, rs#1801131) and MTRR (A66G, rs#1801394) in a single tube.
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