Ischemic postconditioning protects against reperfusion injury. Adjunctive use of manual thrombus aspiration improves reperfusion results in patients undergoing primary angioplasty. Combining both strategies (ischemic postconditioning and thrombus aspiration) may have additive effects in terms of myocardial salvage. The PORT trial will study the role of ischemic postconditioning in patients undergoing primary angioplasty with thrombus aspiration.
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Front Genet
November 2024
Department of Emergency, Wenzhou People's Hospital, The Third Affiliated to Shanghai University, Wenzhou, Zhejiang, China.
Article Synopsis
- Ischemic post-conditioning (I-post C) is a method used to protect lung tissue from damage due to ischemia/reperfusion injury, but the exact mechanisms behind its protective effects are not well understood.
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New alternative approaches to stroke treatment: the blood cell-derived secretome shows promise in individuals with obesity.
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Biomedical Research Center of the Slovak Academy of Sciences, Institute of Neurobiology, Soltesovej 4-6, 040 01, Košice, Slovak Republic.
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View Article and Find Full Text PDFSevoflurane postconditioning mitigates neuronal hypoxic-ischemic injury via regulating reactive astrocytic STAT3 protein modification.
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Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. Electronic address:
Astrocyte activation plays a pivotal role in accelerating the cascade of neuroinflammation associated with the development of hypoxic-ischemic brain injury. This study aimed to investigate the mechanism by which sevoflurane postconditioning mitigates neuronal damage through astrocytes by regulating reactive astrocytic Signal Transducer and Activator of Transcription 3 (STAT3) modifications. A modified Rice‒Vannucci model in rats and a conditioned culture system established by subjecting primary astrocytes to oxygen glucose deprivation, followed by using the conditioned medium to culture the neuron cell line SH-SY5Y were used to simulate HI insult in vivo and in vitro, respectively.
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