AI Article Synopsis
- Many patients on hemodialysis still have functioning kidneys (residual renal function or RRF), but measuring it typically requires inconvenient urine collections for urea and creatinine clearances.
- There is a growing need for alternative methods to assess RRF that do not rely on these collections, as RRF is valuable for clinical decisions and prognosis.
- This article examines blood-based biomarkers and innovative techniques using exogenous filtration markers that could help estimate RRF in hemodialysis patients more easily.
Article Abstract
Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and creatinine clearances. Urine collections are difficult and inconvenient for patients and staff, and therefore RRF is not universally measured. Methods to assess RRF without reliance on urine collections are needed since RRF provides useful clinical and prognostic information and also permits the application of incremental hemodialysis techniques. Significant efforts have been made to explore the use of serum based biomarkers such as cystatin C, β-trace protein and β -microglobulin to estimate RRF. This article reviews blood-based biomarkers and novel methods using exogenous filtration markers which show potential in estimating RRF in hemodialysis patients without the need for urine collection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/sdi.12557 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!