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C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk.
Theranostics
January 2025
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
To establish the extent, distribution and frequency of in-vivo vessel wall [Ga]Ga-PentixaFor uptake and to determine its relationship with calcified atherosclerotic plaque burden (CAP) and cardiovascular risk factors (CVRF). 65 oncological patients undergoing [Ga]Ga-PentixaFor PET/CT were assessed. Radiotracer uptake (target-to-background ratio [TBR]) and CAP burden (including number of CAP sites, calcification circumference and thickness) in seven major vessel segments per patient were determined.
View Article and Find Full Text PDFPharmacokinetics, mass balance, and metabolism of [C]PLB1004, a selective and irreversible EGFR-TKI in humans.
Cancer Chemother Pharmacol
January 2025
Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, 250014, China.
Purpose: PLB1004, developed by Beijing Avistone Biotechnology Co., Ltd., is a safe, highly selective, and efficient irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) employed in treating non-small-cell-lung-cancer (NSCLC).
View Article and Find Full Text PDFGafchromic Films as a Complementary In-field Dosimetric Tool to Monitor Low Photon Radiation Doses (≤50 mSv).
Health Phys
January 2025
Department of Physics, Toronto Metropolitan University, 350 Victoria Street, Toronto, Ontario, M5B 2K3.
This study elucidated the radiation response characteristics of a Gafchromic radiochromic film subjected to low photon doses of ≤50 mSv, which corresponds to the annual whole body effective dose limit for radiation workers in Canada. Radiochromic films are investigated for possible use as a complementary tool for the Canadian Armed Forces that can be worn in addition to their existing personal dosimetry to quickly assess personal radiation dose received from radiological hazards without reliance on electronics. The films were exposed to varying photon energies emanating from x-ray generators and radioisotopes, specifically cesium-137, cobalt-60, and americium-241.
View Article and Find Full Text PDFDosimetry for Radiopharmaceutical Therapy: Practical Implementation, From the Special Series on Quantitative Imaging.
AJR Am J Roentgenol
January 2025
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY.
Radiopharmaceutical therapy (RPT) is advancing rapidly and achieving wider clinical application. However, RPT is not yet optimized in practice, as tumor and normal-organ dose estimates and, in turn, dose-response relationships remain poorly defined. Internal dosimetry is evolving to address such issues, transitioning from the estimation of population-average organ-level or tumor-level doses to individualized patient-specific sub-organ or sub-tumor doses.
View Article and Find Full Text PDFImply on diagnosis and early prognosis of preoperative [Ga]Ga-PSMA-11 PET/CT in patients with suspected brain tumours of glial origin.
Sci Rep
January 2025
Nuclear Medicine Department, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.
PET/CT targeting prostate-specific membrane antigen (PSMA) is commonly used in patients with prostate cancer. PSMA has been found in other solid tumours, including primary brain tumours. The aim of this study was to evaluate the usefulness of [Ga]Ga-PSMA-11 PET/CT for preoperative diagnosis and 2-year prognosis.
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