The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395365 | PMC |
| http://dx.doi.org/10.1021/jacs.6b08932 | DOI Listing |
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