AI Article Synopsis
- Emerging research shows a potential link between infections outside the central nervous system and a heightened risk of dementia, but data is still limited.
- A study of over 417,000 US veterans aged 56 and older found significant associations between various types of bacterial infections and an increased risk of dementia, particularly infections like septicemia and pneumonia.
- These findings suggest that both systemic and localized bacterial infections may contribute to the development of dementia, highlighting the need for further investigation.
Article Abstract
Introduction: Emerging evidence indicates associations between extra-central nervous system (CNS) bacterial infections and an increased risk for dementia; however, epidemiological evidence is still very limited.
Methods: This study involved a retrospective cohort of a national sample of US veterans ( = 417,172) aged ≥56 years. Extended Cox proportional hazard models adjusted for demographic characteristics and medical and psychiatric comorbidities determined the associations between systemic and localized extra-CNS bacterial infections occurring >2 years before the initial dementia diagnosis and the risk for dementia.
Results: Exposure to any extra-CNS bacterial infection was associated with a significantly increased risk for dementia (hazard ratio [HR] = 1.20 [95% confidence interval = 1.16-1.24]). Independently, septicemia (HR = 1.39 [1.16-1.66]), bacteremia (HR = 1.22 [1.00-1.49]), osteomyelitis (HR = 1.20 [1.06-1.37]), pneumonia (HR = 1.10 [1.02-1.19]), urinary tract infections (HR = 1.13 [1.08-1.18]), and cellulitis (HR = 1.14 [1.09-1.20]) were associated with a significantly increased risk for dementia.
Discussion: Both systemic and localized extra-CNS bacterial infections are associated with an increased risk for developing dementia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061465 | PMC |
| http://dx.doi.org/10.1016/j.dadm.2016.08.004 | DOI Listing |
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