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Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial.
Anesthesiology
December 2024
Department of Critical Care, The University of Melbourne, Melbourne, Australia.
Background: In the PROTECTION trial, intravenous amino acids (AA) decreased the occurrence of acute kidney injury (AKI) in cardiac surgery patients with cardiopulmonary bypass (CPB). Recruitment of renal functional reserve may be responsible for such protection. However, patients with chronic kidney disease (CKD) have diminished renal functional reserve, and AA may be less protective in such patients.
View Article and Find Full Text PDFA pain research strategy for Europe: A European survey and position paper of the European Pain Federation EFIC.
Eur J Pain
January 2025
UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Background: Pain is the leading cause of disability and reduced quality of life worldwide. Despite the increasing burden for patients and healthcare systems, pain research remains underfunded and under focused. Having stakeholders identify and prioritize areas that need urgent attention in the field will help focus funding topics, reduce 'research waste', improve the effectiveness of pain research and therapy and promote the uptake of research evidence.
View Article and Find Full Text PDFHospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes.
NPJ Genom Med
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Children's Rare Disease Collaborative, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital has established a genomic sequencing and analysis research initiative to improve clinical care for pediatric rare disease patients. Through the Children's Rare Disease Collaborative (CRDC), the hospital offers CLIA-grade exome and genome sequencing, along with other sequencing types, to patients enrolled in specialized rare disease research studies. The data, consented for broad research use, are harmonized and analyzed with CRDC-supported variant interpretation tools.
View Article and Find Full Text PDFMortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials.
Crit Care
November 2024
Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, University of Bielefeld, Burgsteig 13, Haus Gilead I, 33617, Bielefeld, Germany.
Background: Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thus performed a meta-analysis, including the most recent data, to evaluate the potential impacts of treatment with short-acting betablockers on mortality in adult septic patients.
View Article and Find Full Text PDFCurrent insights in ultra-rare adenylosuccinate synthetase 1 myopathy - meeting report on the First Clinical and Scientific Conference. 3 June 2024, National Centre for Advancing Translational Science, Rockville, Maryland, the United States of America.
Orphanet J Rare Dis
November 2024
Cure ADSSL1, Glendale, CA, USA.
Article Synopsis
- The first Clinical and Scientific Conference on ADSS1 myopathy took place on June 3, 2024, at NIH in Maryland, focusing on this rare inherited neuromuscular disease.
- The conference highlighted geographical patient clusters from South Korea, Japan, India, and the USA, along with research on pre-clinical models to better understand the disease.
- Experts identified biochemical pathways for potential therapies and created an ADSS1 myopathy consortium to guide new treatment development.
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