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Regional Anesthesia and Surgical Volume in Children Undergoing Nuss Repair: A Multicenter Review.
J Surg Res
December 2024
University of Michigan Health, C.S. Mott Children's Hospital, Ann Arbor, Michigan.
Introduction: Regional anesthetic approach and surgical volume have been shown to outcomes in patients undergoing Nuss procedure for pectus excavatum. However, their independent relationship is not described. We investigated how regional anesthesia and surgical volume are associated with length of stay (LOS), postoperative opioid use, operating room utilization, and complications.
View Article and Find Full Text PDFThe effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better.
Cardiovasc Diabetol
November 2024
Department of Medicine, Surgery and Dentistry, Schola Medica Salernitana, University of Salerno, Via Salvador Allende, 84081, Baronissi, Salerno, Italy.
Background: Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i) represent a deep revolution of the therapeutic approach to heart failure (HF), preventing its insurgence but also improving the management of the disease and slowing its natural progression. To date, few studies have explored the effectiveness of SGLT2i and, in particular, Dapagliflozin in a real-world population. Therefore, in this observational prospective study, we evaluated Dapagliflozin's effectiveness in a real-world HF population categorized in the different hemodynamic profiles.
View Article and Find Full Text PDFState of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases.
Eur J Heart Fail
November 2024
Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
Article Synopsis
- * Advanced techniques such as adeno-associated viral vectors and CRISPR-Cas9 are proving to be efficient for gene delivery and repairing genetic issues in humans.
- * The statement reviews various gene therapy approaches for heart failure and its causes, discusses their clinical applications, and highlights safety concerns and regulatory challenges for future development.
National health expenditure per capita is associated with CRT implantation practice: findings from the ESC CRT Survey II with 11 088 patients.
Eur Heart J Qual Care Clin Outcomes
November 2024
Cardiology Department, Stavanger University Hospital, Gerd-Ragna Bloch Thorsens gate 8, 4011 Stavanger, Norway.
Aims: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in selected patients with heart failure (HF) and electrical dyssynchrony. This treatment receives class IA recommendations in European Society of Cardiology (ESC) guidelines. However, despite these strong recommendations, CRT implantation practice varies greatly in Europe.
View Article and Find Full Text PDFMachine-learning-based prediction of cardiovascular events for hyperlipidemia population with lipid variability and remnant cholesterol as biomarkers.
Health Inf Sci Syst
December 2024
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong China.
Article Synopsis
- Dyslipidemia significantly increases the risk of developing cardiovascular diseases (CVD), highlighting the need for better predictive models tailored for those with high lipid levels.
- Researchers conducted a study using data from over 23,000 hyperlipidemic patients to test machine-learning algorithms against traditional risk assessment tools for predicting CVD onset.
- The LightGBM algorithm performed best with an AUROC of 0.883, surpassing the logistic regression model (0.725) and traditional risk scores, while findings suggested that blood lipid levels and remnant cholesterol are key indicators of CVD risk.
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