Cardiovascular patients frequently use herbal medicinal products, in order to contribute to the improvement of their chronic condition without medical intervention. However, they are likely to suffer from adverse effects from natural products and herb-drug interactions. In this work we present the results collected from a public campaign "Learning Health, among Plants and Medicines", carried out by the Observatory of Herb-Drug Interactions (www.oipm.uc.pt), to alert cardiovascular patients and healthcare providers for the potential occurrence of herb-drug interactions with cardiovascular therapy. From the data received, it was highlighted the prevalence of certain natural products used by many cardiovascular patients in Portugal, particularly goji berries, green tea, mangosteen and rooibos that have significant cardiovascular effects. For this reason their intake should be carefully monitored in these patients. This prevalence of consumption suggests a pattern in their use in Portugal and a prevention of herb-drug interactions should be carried out by the health professionals. The ending results also indicate that there is still a lack of knowledge about the possible risks of herbal products intake, which may adversely affect the health of any patient. Thus becomes clear the value of the role of health professionals in the screening of such interactions.
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http://dx.doi.org/10.2174/1871525714666161007154234 | DOI Listing |
Biochimie
March 2025
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address:
Metformin, initially prescribed as an oral hypoglycemic medication for type 2 diabetes, has recently gained attention for its potential anticancer effects. Its history dates to 1918, when guanidine, a component of the traditional European herb Galega officinalis, was found to reduce glycemia. This review precisely examines the mechanisms underlying Metformin's anticancer effects across various neoplastic conditions.
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March 2025
Department of Pharmacy Practice, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
BACKGROUND Herbal medicine is commonly used in Saudi Arabia, and is widely viewed as natural and safe. However, its use among transplant recipients poses risks due to interactions with immunosuppressive therapies. This study explores herbal medicine use, knowledge, and attitudes among Saudi transplant recipients.
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June 2025
Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged. This study investigated the inhibitory effects of Kratom leaf constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone (4MU) glucuronidation by a panel of recombinant human UGT enzymes, including UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B7, and UGT2B15. The degree of inhibition exhibited by mitragynine and 7-hydroxymitragynine on UGTs varied.
View Article and Find Full Text PDFDrug Metab Dispos
February 2025
Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama. Electronic address:
It is important to understand the potential of botanical-drug interactions to ensure the safe use of botanical dietary supplements (BDS). Cytochrome P450 (P450) is one of the most abundant phase 1 drug-metabolizing enzymes and is accountable for a great deal of pharmacokinetic botanical-drug interactions. This problem is particularly acute for older adults who often consume BDS with multiple prescription medicines.
View Article and Find Full Text PDFComput Biol Chem
April 2025
Department of Dermatology, The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, China. Electronic address:
Objective: Psoriasis is a common clinical skin inflammatory disease. Haitang-Xiaoyin Mixture (HXM) represents a traditional Chinese medicine formulation utilized clinically for the management of psoriasis, which can reduce the psoriasis area and severity index (PASI) score, IL-23 and IL-23 levels in patients with psoriasis. However, the main active components and specific targets of HXM in the treatment of psoriasis and the relevant mechanisms of action are not clear.
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