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[Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient].
Ann Pathol
March 1994
Service de Dermatopathologie, CHU du Sart Tilman, Université de Liège.
We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.
View Article and Find Full Text PDFAn animal model for the study of azidothymidine-induced hyperpigmentation.
Lab Invest
March 1991
Department of Laboratory Medicine, University of California School of Medicine, San Francisco.
Mice fed azidothymidine demonstrated dramatic hyperpigmentation of their tails. Histologic examination demonstrated large quantities of melanin pigment throughout the entire epidermal layer. Control mice had scant melanin pigment localized to the basal layer.
View Article and Find Full Text PDFAzidothymidine-induced hyperpigmentation mimicking primary adrenal insufficiency.
Am J Med
April 1989
Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colorado 80045-5001.
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