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Bivalirudin as an anticoagulation strategy for acute hemodialysis in children: Two cases with a summary of recent literature.
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Department of Pediatric Nephrology, Member of the European Reference Network for Rare Kidney Diseases (ERKNet), Ghent University Hospital, Ghent, Belgium.
Unfractionated heparin is the most used anticoagulative agent for extracorporeal settings in children, including acute hemodialysis modalities. In certain situations, such as heparin-induced thrombocytopenia, alternatives must be applied. The direct thrombin inhibitor bivalirudin has come forth as an attractive substitute.
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Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome is a severe adverse drug reaction marked by delayed hypersensitivity reactions causing skin and systemic complications. DRESS diagnosis is challenging due to the variety of clinical presentations and symptom overlap with other conditions. The perioperative period in these patients requires precise pharmacological strategies to prevent complications associated with this syndrome.
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