The NHS is introducing a set of information technology-based service improvement tools as part of its quality, innovation, productivity and prevention scheme, to drive up quality, drive out inefficiencies and drive down costs in healthcare services. these tools include clinical dashboards, nhs Comparators and nhs Choices.
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| http://dx.doi.org/10.7748/nm.16.9.8.s13 | DOI Listing |
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Theta and alpha connectivity in children with autism spectrum disorder.
Brain Commun
February 2025
Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.
Spontaneous electroencephalography (EEG) measurements have demonstrated putative variations in the neural connectivity of subjects with autism spectrum disorder, as compared to neurotypical individuals. However, the exact nature of these connectivity differences has remained unknown, a question that we now address. Resting-state, eyes-open EEG data were recorded over 20 min from a cohort of 13 males aged 3-5 years with autism spectrum disorder, and nine neurotypical individuals as a control group.
View Article and Find Full Text PDFExploring functional connectivity in clinical and data-driven groups of preterm and term adults.
Brain Commun
February 2025
Department of Early Life Imaging, School of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EH, UK.
Adults born very preterm (i.e. at <33 weeks' gestation) are more susceptible to long-lasting structural and functional brain alterations and cognitive and socio-emotional difficulties, compared with full-term controls.
View Article and Find Full Text PDFCost-Effectiveness of Nirmatrelvir/Ritonavir in COVID-19 Patients at High-Risk for Progression in Spain.
J Med Virol
March 2025
Pfizer S.L.U, Madrid, Spain.
The objective was to estimate the cost-effectiveness of nirmatrelvir/ritonavir (NMV/r) in treating adults with COVID-19 at high-risk of developing severe COVID-19 who do not require supplemental oxygen, compared to no treatment, from the Spanish National Health System (NHS) perspective. A decision-tree for the first year followed by a two-state Markov model with annual cycles for a lifetime horizon was developed. A cohort of 1000 high-risk, symptomatic COVID-19 patients entered the decision-tree for each comparator, divided into hospitalized patients, considering their level of care, and outpatients, for whom only symptom duration was considered.
View Article and Find Full Text PDFA cohort evaluation of surgical pathways reported to national audit for children undergoing treatment for congenital heart disease in England and Wales.
J Thorac Cardiovasc Surg
March 2025
Clinical Operational Research Unit, University College London.
Objectives: We aimed to ascertain rates of completion of essential cardiac procedures and their overall contribution to longer-term mortality in children with congenital heart disease (CHD).
Methods: Cohort study using the United Kingdom National CHD Audit. For 9 sentinel CHDs (hypoplastic left heart syndrome (HLHS), non-HLHS functionally univentricular heart, ventricular septal defect, tetralogy of Fallot, coarctation, aortic stenosis, atrioventricular septal defect, transposition of the great arteries and pulmonary atresia) we described the pathway operations required for treatment that were undertaken at population-level, and the mortality associated with these pathway operations by age 5-years.
High and low take-off external prolapse phenotypes can be characterised preoperatively on defaecation proctography.
Tech Coloproctol
March 2025
Department of Colorectal Surgery, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 7LE, UK.
Background: External rectal prolapse is poorly understood, with controversy surrounding the ideal surgical approach. Anecdotal mentions of high and low take-off in the literature hint at different pathological phenotypes of prolapse. However there has been no effort to define and characterise these terms, or to discuss how take-off might relate to the underlying pathophysiology of prolapse.
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