Diversity in the macrophage models currently employed in immunology studies may lead to opposed results and interpretations. In this study, we aimed to analyze the suitability of J774 macrophage-like cells as a model for the interaction between the dermatophyte Trichophyton rubrum and macrophages. J774 cells were competent in fungal phagocytosis, but succumbed to hyphal growth. Nevertheless, they could also secrete IL-1β in response to the dermatophyte. On the opposite direction, inflammatory, thioglycollate-induced peritoneal macrophages did not succumb to fungal growth and showed no significant IL-1β production. The proteomic profiling of these cells uncovered vimentin and plastin-2 as proteins whose abundance was altered by the fungal interaction. Our study indicates that this cell line could be an interesting tool in the investigation of T. rubrum infection biology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11046-016-0077-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and Clinical Detection of Rapid Molecular Diagnostic System for Pathogenic Dermatophytes of Tinea Capitis of Multiple Centres in China.
Mycoses
January 2025
Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Objectives: Tinea capitis remains a common fungal infection in children worldwide. Species identification is critical for determining the source of infection and reducing transmission. In conventional methods, macro- and microscopic analysis is time-consuming and results in slow fungal growth or low specificity.
View Article and Find Full Text PDFMolecular epidemiology of dermatophytosis in Golestan, Iran: A cross-sectional study.
Microb Pathog
December 2024
Invasive Fungi Research Center, Communicable Diseases Institute/Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
Keratinophilic fungi, or dermatophytes, are recognized as the predominant fungal agents responsible for superficial skin diseases globally. The identification of species of dermatophytes is crucial for both therapeutic and epidemiological considerations. The primary objective of the present study was to investigate the epidemiology of dermatophytosis among patients who sought medical attention at the medical mycology laboratory in Golestan province.
View Article and Find Full Text PDFDemographic and Pathogen Profiles of Superficial Fungal Infections-A Single-Centre Observational Study in Poland.
Mycoses
December 2024
Department of Dermato-Venereology, 4 Th Military Hospital, Wroclaw, Poland.
Background: Superficial fungal infections (SFI) are contagious conditions affecting the skin and its appendages, caused by various fungal species. Monitoring the distribution of common pathogens and identifying at-risk patient groups are essential for effective management and prevention.
Objectives: This study investigates the characteristics of SFI in Poland's Malopolska region from 2017 to 2019, focusing on etiological agents, infection sites and risk factors.
The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes in .
Int J Mol Sci
December 2024
Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Fungi can remarkably sense and adapt to various extracellular stimuli and stress conditions. Oxidative stress, which results from an imbalance between reactive oxygen species production and antioxidant defenses, leads to cellular damage and death. In , oxidative stress is managed by a complex antioxidant system, including thioredoxins, glutathione, catalases, peroxidases, and superoxide dismutase, with glutathione playing a crucial role.
View Article and Find Full Text PDFClinico-Mycological Study of Dermatophytosis among Diabetic and Non-Diabetic Patients in a Tertiary Level Hospital: A Comparative Study.
Indian J Dermatol
October 2024
Department of Microbiology, JSS Medical College and Hospital, JSS Academy of Higher Education (Deemed to be University), Mysuru, Karnataka, India.
Background: Dermatophytosis is a major public health concern in India, especially in recent years, with an alarmingly rising trend, particularly in relation to recurrent and chronic infection. The number of studies examining the relationship between an individual's glycemic status and the development of dermatophytosis, and a comparison of the evolving species trend between diabetic and non-diabetic patients infected with dermatophytes, is limited.
Aims And Objectives: To study and compare the clinical and mycological aspects of dermatophytosis among diabetic and non-diabetic patients and to compare the culture isolates in both groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!