Aim: Tunable size ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles from 3 to 9 nm coated with polyethylene glycol phosphonate moieties have been designed for neovascularization MRI.
Materials & Methods: USPIO were synthesized using a nonaqueous sol-gel method. An ischemia-reperfusion rat model has been chosen for neo-angiogenesis and scanned on MRI after injection of different sized USPIO. Histological studies have been performed for USPIO localization within the tissue.
Results: The magnetic properties and consequently their MRI relaxivities are drastically dependent on the crystalline core size. In vivo MRI spots were observed specifically in the ischemic area. The best MRI contrast within neovascularization is generated by 6 nm nanoparticles proving that compromise between T relaxivity and physico-chemical properties is essential for the design of effective MRI contrast agent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nnm-2016-0177 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of T1-weighted and augmented T1-weighted images of multi-parametric MR sequence in detecting neonatal punctate white matter lesions.
Magn Reson Imaging
December 2024
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. Electronic address:
Background And Purpose: Punctate White Matter Lesion (PWML) is common in neonates. Multi-parametric MR imaging with flexible design (MULTIPLEX, MTP) generates multiple requires only about 6 min for full-head coverage. This study aimed to evaluate the value of T1WI and aT1WI contrasts of MTP in detecting neonatal punctate white matter lesions.
View Article and Find Full Text PDFCardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal.
Neuroimage
December 2024
Medical Image Processing Department, CHU Amiens-Picardie University Hospital, Amiens, France; CHIMERE UR 7516, University of Picardie Jules Verne, Amiens, France. Electronic address:
Understanding cerebrospinal fluid (CSF) dynamics is crucial for elucidating the pathogenesis and diagnosis of neurodegenerative diseases. The primary mechanisms driving CSF oscillations remain a topic of debate. This study investigates whether cerebral blood volume displacement (CBV), modulated by breathing and cardiac activity, are the predominant drivers of CSF oscillations.
View Article and Find Full Text PDFSTUDY OF ORBITAL NEOPLASMS BY MAGNETIC RESONANCE IMAGING PROCEDURE.
Georgian Med News
October 2024
2Tbilisi State Medical University, Clinical Professor, Tbilisi, Georgia.
The neoplasms of the organ of vision are characterized by significant polymorphism, which is due to the histological diversity of the structures in the eye socket. Almost all types of neoplasms described in humans are found in the orbit. The study aimed to determine the diagnostic value of magnetic resonance imaging in patients with tumors in the eyeball and the eye socket, as well as to determine the superiority of the MRI procedure compared to other instrumental methods of research.
View Article and Find Full Text PDFDecoding Brain Development and Aging: Pioneering Insights From MRI Techniques.
Invest Radiol
October 2024
From the Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan (A.H., S.K., J.K., M.N., W.U., S.F., T.A., A.W., K.K., S.A.); Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (A.H., M.N., S.F.); Polytechnique Montréal, Montreal, Quebec, Canada (S.N.); Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada (S.N.); and Center for Advanced Interdisciplinary Research, Ss. Cyril and Methodius University in Skopje, Skopje, North Macedonia (S.N.).
The aging process induces a variety of changes in the brain detectable by magnetic resonance imaging (MRI). These changes include alterations in brain volume, fluid-attenuated inversion recovery (FLAIR) white matter hyperintense lesions, and variations in tissue properties such as relaxivity, myelin, iron content, neurite density, and other microstructures. Each MRI technique offers unique insights into the structural and compositional changes occurring in the brain due to normal aging or neurodegenerative diseases.
View Article and Find Full Text PDFGadopiclenol: A q = 2 Gadolinium-Based MRI Contrast Agent Combining High Stability and Efficacy.
Invest Radiol
October 2024
From the Research and Innovation Department, Guerbet, Roissy, France (I.M., M.-C.D.G., J.-F.M., A.D., Y.B., N.D., I.S., G.B., C.M., C.F., O.R., S.C.); General, Organic, and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium (C.H., S.L.); and Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany (C.K., T.J.M., U.K.).
Objectives: Gadopiclenol is a q = 2 pyclen gadolinium-based contrast agent (GBCA) recently approved by the Food and Drug Administration, European Medicines Agency, and other European countries. The aim of this report is to demonstrate its stability in multiple stressed in vitro conditions and in vivo, in rat kidney, while maintaining its higher relaxivity compared with conventional GBCAs on the market.
Materials And Methods: Both gadopiclenol and its chemical precursor Pi828-Gd were characterized and compared with q = 1 gadolinium (Gd) complexes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!