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Microfluidic Approach to Cell Microencapsulation. | LitMetric

Microfluidic Approach to Cell Microencapsulation.

Methods Mol Biol

Lawrence Berkeley National Laboratory, 1 Cyclotron Road Mailstop XXX, Berkeley, CA, 94720, USA.

Published: December 2017

Bioartificial pancreas made of insulin-secreting islets cells holds great promise in the treatment of individuals with Type-1 diabetes. Successful islet cell microencapsulation in biopolymers is a key step for providing immunoisolation of transplanted islet cells. Because of the variability in the size and shape of pancreatic islets, one of the main obstacles in their microencapsulation is the inability to consistently control shape, size, and microstructure of the encapsulating biopolymer capsule. In this chapter, we provide a detailed description of a microfluidic approach to islet cell encapsulation in alginate that might address the microencapsulation challenges.

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Source
http://dx.doi.org/10.1007/978-1-4939-6364-5_5DOI Listing

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