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Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes.
Proc Natl Acad Sci U S A
December 2024
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Neurofilaments (NFs) are multisubunit, bottlebrush-shaped intermediate filaments abundant in the axonal cytoskeleton. Each NF subunit contains a long intrinsically disordered tail domain, which protrudes from the NF core to form a "brush" surrounding each NF. Precisely how the tails' variable charge patterns and repetitive phosphorylation sites mediate their conformation within the brush remains an open question in axonal biology.
View Article and Find Full Text PDFA widespread phage-encoded kinase enables evasion of multiple host antiphage defence systems.
Nat Microbiol
December 2024
Department of Burn and Plastic Surgery, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
DNA degradation (Dnd) is a widespread bacterial antiphage defence system that relies on DNA phosphorothioate (PT) modification for self/non-self discrimination and subsequent degradation of unmodified DNA. Phages employ counterstrategies to evade host immunity, but anti-Dnd immunity has not been characterized. Here we report an immune evasion protein encoded by the Salmonella phage JSS1 that contributes to subverting Dnd and other defence systems.
View Article and Find Full Text PDFConnectivity of Parameter Regions of Multistationarity for Multisite Phosphorylation Networks.
Bull Math Biol
November 2024
University of Copenhagen, Copenhagen, Denmark.
The parameter region of multistationarity of a reaction network contains all the parameters for which the associated dynamical system exhibits multiple steady states. Describing this region is challenging and remains an active area of research. In this paper, we concentrate on two biologically relevant families of reaction networks that model multisite phosphorylation and dephosphorylation of a substrate at n sites.
View Article and Find Full Text PDFNegative effect of treatment with mGluR5 negative allosteric modulator AFQ056 on blood biomarkers in young individuals with Fragile X syndrome.
SAGE Open Med
September 2024
MIND Institute, University of California Davis, Sacramento, CA, USA.
Background: Fragile X syndrome, with an approximate incidence rate of 1 in 4000 males to 1 in 8000 females, is the most prevalent genetic cause of heritable intellectual disability and the most common monogenic cause of autism spectrum disorder. The full mutation of the Fragile X Messenger Ribonucleoprotein-1 gene, characterized by an expansion of CGG trinucleotide repeats (>200 CGG repeats), leads to fragile X syndrome. Currently, there are no targeted treatments available for fragile X syndrome.
View Article and Find Full Text PDFAsp/ASPM phospho-regulation throughout the cell cycle.
Genome
October 2024
Department of Biology, Mount St. Vincent University, Halifax, NS B3M 2J6, Canada.
In mammals and , Asp/ASPM proteins contribute to cell proliferation and spindle formation. Recent evidence also suggests interphase roles for Asp/ASPM proteins, but little is known about the regulation allowing distinct roles in different cell cycle phases. In this review, we consider a cross-species comparison of Asp/ASPM protein sequences in light of cyclin-CDK literature, and suggest Asp/ASPM proteins to be prime candidates for cyclin-CDK regulation.
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