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Article Synopsis
  • Sarcoidosis can be tricky to diagnose because it shares symptoms with cancers; this report discusses a case of a woman with both ovarian and endometrial cancers who had unusual lung findings after treatment.
  • Imaging suggested cancer recurrence due to the presence of lung nodules and swollen lymph nodes, but further tests showed no cancer cells, only inflammation from treatment.
  • The inflammation surprisingly went away on its own, highlighting the need for teamwork in medical diagnoses and the critical role of lab tests in differentiating between actual cancer and reactions to chemotherapy.
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Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases.

Surg Case Rep

September 2023

Department of Gastroenterological Surgery, Saitama Cancer Center, 780 Komuro, Ina-Machi, Kita-Adachi-Gun, Saitama, 362-0806, Japan.

Background: Tumor-associated sarcoid reactions have been observed with various tumors; however, they have not been reported with uterine cancer. We present two cases of splenic sarcoid reactions that mimicked metastases a few years after uterine cancer surgery.

Case Presentation: Case 1 involved a 67-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1).

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A 77-year old lady with previously treated endometrial sarcoma presented with progressive left upper lid mechanical ptosis secondary to superior orbital mass. An orbital biopsy confirmed the diagnosis of orbital sarcoidosis. Further systemic work up revealed suspicious pulmonary nodules which were found to be endometrial sarcoma metastases rather than systemic sarcoidosis on image guided biopsy.

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Purpose: To identify the imaging features indicative of sarcoid-like reactions in patients with intrathoracic lymphadenopathy after complete remission of malignancies.

Materials And Methods: This study enrolled five patients with histopathologically confirmed sarcoid-like reactions that developed after cancer remission. The clinical features and findings of CT and F-fluorodeoxyglucose (FDG) PET/CT were assessed.

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