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Cell envelope polysaccharide modifications alter the surface properties and interactions of with innate immune cells in a morphotype-dependent manner.
mBio
March 2025
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
is one of the leading causes of pulmonary infections caused by non-tuberculous mycobacteria. The ability of to establish a chronic infection in the lung relies on a series of adaptive mutations impacting, in part, global regulators and cell envelope biosynthetic enzymes. One of the genes under strong evolutionary pressure during host adaptation is , which participates in the elaboration of the arabinan domains of two major cell envelope polysaccharides: arabinogalactan (AG) and lipoarabinomannan (LAM).
View Article and Find Full Text PDFRe-Evaluating the Use of Glyphosate-based Herbicides: Implications on Fertility.
Reprod Sci
March 2025
Departments of Obstetrics and Gynecology and Biochemistry and Molecular Biology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Glyphosate-based herbicides (GBHs) are the most widely used herbicides in the United States, accounting for 19% of estimated global use. Although the Environmental Protection Agency (EPA) has reaffirmed that the active ingredient glyphosate (GLY) is safe for humans, recent studies on exposure have suggested association with cancer, metabolic disorders, endocrine disruption and infertility, Alzheimer's and Parkinson's disease, and psychological disorders. Current literature on the effects of GLY exposure on reproductive function suggests potential clinical implications on women's reproductive health, including polycystic ovarian syndrome (PCOS), endometriosis, infertility, and adverse pregnancy outcomes.
View Article and Find Full Text PDFMonitoring the mitochondrial localization of mycobacterial proteins.
Methods Cell Biol
March 2025
Department of Biochemistry, School of Life Sciences, University of Hyderabad, India. Electronic address:
Mitochondrion apart from being the energy hub of the cell, is also the center of various signaling pathways. During intracellular infection, either bacterial or viral, several pathogen proteins, metabolites, and possibly, lipids interact with the host mitochondria. These interactions allow the pathogens, such as Mtb, to reprogram the host mitochondrial functions, screwing the host immune responses and resulting in the persistence of the bacteria.
View Article and Find Full Text PDFInvolvement of Mycobacterium smegmatis small noncoding RNA B11 in triacylglycerol accumulation and altered cell wall permeability.
BMC Microbiol
March 2025
Key Laboratory of Translational Medicine of Guangdong, Center for Tuberculosis Control of Guangdong Province, Guangzhou, Guangdong, China.
Background: Pathways involving triacylglycerol (TAG) accumulation are thought to play a crucial regulatory role in bacterial growth and metabolism. Despite this understanding, little is known about the biological functions and regulatory mechanisms of small RNAs in Mycobacterium. Mycobacterium smegmatis (M.
View Article and Find Full Text PDFGuidance for shared decision-making regarding orchiectomy in individuals with differences of sex development due to 17-β-hydroxysteroid dehydrogenase type 3 deficiency.
Front Pediatr
February 2025
University of Cincinnati College of Medicine, Cincinnati, OH, United States.
17β-hydroxysteroid dehydrogenase type 3 deficiency is a 46,XY difference of sex development (DSD) that may present in childhood with inguinal testes or at puberty following virilization. We present four individuals, assigned female at birth, to highlight complexities and considerations surrounding orchiectomy. We reviewed the literature and created a "FACT sheet" to guide shared decision-making for patients, parents, and providers.
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