Ten healthy volunteers received oxygen for 1 min, 2 min and 3 min at 10 l.min via a face mask, or humidified oxygen at 60 l.min via nasal prongs (Optiflow ) with the mouth closed and with the mouth open. The mean (SD) end-tidal oxygen partial pressure after 3 min face mask and Optiflow oxygenation, with mouth closed and open, were: 88.5 (6.2) kPa; 85.6 (6.4) kPa and 48.7 (26.4) kPa, respectively, p = 0.001. The equivalent mean (SD) transcutaneous oxygen partial pressures were: 34.6 (5.4) kPa; 36.4 (6.5) kPa and 25.5 (15.7) kPa, respectively, p = 0.03. High-flow humidified nasal oxygenation for 3 min with the mouth closed was as effective as 3 min face mask oxygenation.
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http://dx.doi.org/10.1111/anae.13607 | DOI Listing |
PLoS One
January 2025
European Commission, Joint Research Centre (JRC), Ispra, Italy.
Disposable filtering face piece respirators (FFRs) are not approved for reuse as standard of care. However, lessons learnt from the SARS-CoV-2 pandemic, FFRs decontamination and reuse may be needed as crisis capacity strategy to ensure availability in medical facilities. We studied a decontamination methodology based on atmospheric pressure plasma technology, which allows for rapid, contact-free decontamination without utilisation of harmful chemicals, and suitable to access small pores and microscopic filters openings.
View Article and Find Full Text PDFPediatr Res
January 2025
Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, AB, Canada.
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View Article and Find Full Text PDFFront Pharmacol
January 2025
Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Institute of Structural Pharmacology and TCM Chemical Biology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
(Wall.) Lindl. (AR) is a perennial herb that has long been used as medicinal and edible plant.
View Article and Find Full Text PDFEur J Pharm Biopharm
January 2025
Department of Pharmaceutical Technology, University of Regensburg 93053 Regensburg, Bavaria, Germany. Electronic address:
The utilization of targeted nanoparticles as a selective drug delivery system is a powerful tool to increase the amount of active substance reaching the target site. This can increase therapeutic efficacy while reducing adverse drug effects. However, nanoparticles face several challenges: upon injection, the immediate adhesion of plasma proteins may mask targeting ligands, thereby diminishing the target cell selectivity.
View Article and Find Full Text PDFNeuroimage
January 2025
Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine University Duesseldorf, Bergische Landstraße 2, 40629 Duesseldorf, Germany.
Despite their high prevalence, somatoform pain disorders are often not recognized early enough, not diagnosed reliably enough and not treated appropriately. Patients often experience a high level of suffering and the feeling of not being understood. For the medical care system, the symptoms represent a diagnostic and therapeutic challenge.
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